11β-羟类固醇脱氢酶Ⅰ型在代谢综合征中的作用及药物干预研究进展  

Role of 11β- hydroxysteroid dehydrogenase type I in metabolic syndrome and progress of drug intervention

作　　者：孙洁 程立红[1] 闵友江[1,2] SUN Jie;CHENG Lihong;MIN Youjiang(College of Acupuncture and Moxibustion,Jiangxi University of Traditional Chinese Medicine,Nanchang 330000,Jiangxi,China;Department of Traditional Chinese Medicine,Shanghai Eighth People’s Hospital,Shanghai 200235,China)

机构地区：[1]江西中医药大学针灸推拿学院,江西南昌330000 [2]上海市第八人民医院中医科,上海200235

出　　处：《上海中医药杂志》2019年第9期90-94,共5页Shanghai Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81660817)

摘　　要：综述11β-羟类固醇脱氢酶Ⅰ型(11β-HSD1)在代谢综合征中的作用及药物干预研究概况。11β-HSD1在脂肪细胞中通过c-Jun氨基末端激酶(JNK)活化介导胰岛素抵抗;己糖-6-磷酸脱氢酶可活化11β-HSD1,引起胰岛素抵抗;11β-HSD1对海马(杏仁核)-HPA轴有双向调节作用。研究发现,某些中药单体及复方可通过11β-HSD1治疗代谢综合征。This paper reviews the role and research of 11β-hydroxysteroid dehydrogenase type I(11β-HSD1) in metabolic syndrome. 11β-HSD1 mediates insulin resistance in adipocytes via c-Jun N-terminal kinase(JNK) activation;hexose-6-phosphate dehydrogenase activates 11β-HSD1,causing insulin resistance;11β-HSD1 on hippocampus(amygdala)-the HPA axis has a two-way adjustment. It has been found that some of Chinese medicine monomers and compounds can treat metabolic syndrome by regulating the level of 11β-HSD1.

关 键 词：代谢综合征 11β-羟类固醇脱氢酶Ⅰ型 11β-羟类固醇脱氢酶Ⅰ型抑制剂 中药 综述 

分 类 号：R285[医药卫生—中药学]