竞争性内源RNA及其调控网络在皮肤病理性瘢痕中的作用研究进展  

Advances in the research of effects of competing endogenous RNAs and their regulatory networks in pathological scars of skin

作　　者：李敏[1] 刘德伍[2] 雷弯 Li Min;Liu Dewu;Lei Wan(Department of Gynecology and Obstetrics,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China;Department of Burns,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China;Department of Science and Technology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学第一附属医院妇产科,330006 [2]南昌大学第一附属医院烧伤科,330006 [3]南昌大学第一附属医院科技处,330006

出　　处：《中华烧伤杂志》2019年第9期701-704,共4页Chinese Journal of Burns

摘　　要：皮肤病理性瘢痕是一组以成纤维细胞异常增殖、细胞外基质过度沉积为组织学特点的皮肤纤维增生性疾病,发生发展机制不清是制约其诊疗的重要原因。近年来研究证实,微小RNA在病理性瘢痕的调控机制中发挥着重要作用。竞争性内源RNA(ceRNA)由于拥有微小RNA应答元件,可通过海绵吸附作用竞争性结合微小RNA,实现RNA间的相互调节,从而调控靶基因的表达,参与疾病的发展过程。本文从ceRNA假说入手,对ceRNA在皮肤病理性瘢痕发生发展机制中的生物学功能及临床意义进行系统综述,探讨ceRNA及RNA-微小RNA-RNA调节网络在皮肤病理性瘢痕中的作用。ceRNA治疗可能成为未来RNA治疗皮肤瘢痕性疾病的新模式。The skin pathologic scar is a skin fibrous proliferative disease characterized by abnormal proliferation of fibroblasts and overdeposition of extracellular matrix. Unclarity of genesis and development mechanism is the main reason that restricts its diagnosis and treatment. In recent years, it has been found that microRNAs play important roles in the regulation mechanism of pathological scars. The competing endogenous RNAs (ceRNAs) have microRNA response elements which can be competitively combined with microRNAs through sponge adsorption. Through the mutual regulation of RNAs, ceRNAs regulate the expression of target gene and participate in the development of disease. Based on the ceRNA hypothesis, this paper systematically reviews the biological functions and clinical significance of ceRNAs in pathological scars of skin, and discusses the role of ceRNAs and " RNA-microRNA-RNA" regulation network in pathologic scars. The ceRNA therapy may become a new model therapy for skin scars in the future.

关 键 词：核糖核酸酶类 瘢痕 竞争性内源核糖核酸 

分 类 号：R622[医药卫生—整形外科]