毫火针辅助308 nm准分子激光治疗不同部位白癜风疗效观察  

Observation on therapeutic effect of filiform fire needle assisted 308 nm excimer laser on vitiligo of different parts

作　　者：孙璐璐 刘华绪[2] 王真真[2] 王海霞[2] 史纹豪 林燕[2] 郭璇[2] 耿建辉[2] 张福仁[2] SUN Lu-lu;LIU Hua-xu;WANG Zhen-zhen;WANG Hai-xia;SHI Wen-hao;LIN Yan;GUO Xuan;GENG Jian-hui;ZHANG Fu-ren(First Clinical Medical College, Shandong University of TCM, Jinan 250014, China;Shandong Demartological Hospital (Shandong Institute of Dermatology and STD Prevention and Treatment), Jinan 250022)

机构地区：[1]山东中医药大学第一临床医学院,济南250014 [2]山东省皮肤病医院(山东省皮肤病性病防治研究所),济南250022

出　　处：《中国针灸》2019年第9期936-939,952,共5页Chinese Acupuncture & Moxibustion

基　　金：国家自然科学基金项目：81271773;山东省医学科学院医药卫生科技创新工程

摘　　要：目的:比较毫火针辅助308 nm准分子激光与单纯308 nm准分子激光治疗不同部位白癜风的临床疗效。方法:将134例白癜风患者靶皮损按照自身对照原则分为观察组和对照组,各201片。观察组于靶皮损处行毫火针治疗,随后对照组和观察组靶皮损处同时照射308 nm准分子激光,每2周1次,共治疗10次。末次治疗结束后2周评价两组的有效率,两组不同部位的有效率、复色率及见效时间。结果:观察组有效率为82.59%(166/201),高于对照组68.16%(137/201,P<0.01)。观察组面颈、躯干、四肢、手足部的有效率分别为90.32%、81.63%、81.48%、58.62%,高于对照组的82.80%、69.39%、51.85%、31.03%(P<0.01,P<0.05)。观察组各部位的复色率均大于对照组,见效更快(P<0.01,P<0.05)。结论:毫火针作为辅助疗法,联合308 nm准分子激光治疗不同部位白癜风较单纯308 nm准分子激光疗效显著,且联合疗法起效时间更短,其中面颈部白斑疗效最好,手足疗效较差。Objetive To compared the therapeutic effect between filiform fire needle assisted 308 nm excimer laser and simple 308 nm excimer laser on vitiligo of different parts. Methods Target lesions of 134 patients were divided into an observation group and a control group according to the principle of self-controlled, 201 pieces in each one. In the observation group, filiform fire needle was performed at target lesions. Then target lesions both of the two groups were irradiated with 308 nm excimer laser at the same time. Once every 2 weeks, totally 10 treatments were required. The effective rate and effective rate, color recovery rate and responding time of different parts in the two groups were evaluated 2 weeks after treatment. Results The effective rate in the observation group was 82.59%(166/201), which was higher than 68.16%(137/201) in the control group(P<0.01). The effective rate of face-neck, trunk, limbs and hand-foot were 90.32%, 81.63%, 81.48% and 58.62% respectively in the observation group, which were higher than 82.80%, 69.39%,51.85% and 31.03% in the control group(P<0.01, P<0.05). The color recovery rate of different parts in the observation group was higher than the control group, and the effect was faster in the observation group(P<0.01, P<0.05).Conclusion Filiform fire needle as an adjunctive therapy, combined with 308 nm excimer laser are more effective than simple 308 nm excimer laser for vitiligo of different parts. Combination therapy has a shorter responding time, the face-neck has the best effect and hand-foot has poor effect.

关 键 词：白癜风 毫火针 308 nm准分子激光 复色率 见效时间 

分 类 号：R246.7[医药卫生—针灸推拿学]