中风解郁汤治疗脑卒中后抑郁临床研究  

Clinical Study of Decoction for Relieving Stroke and Depression in the Treatment of Post-stroke Depression

作　　者：任伟华[1] 贾奎[1] 刘彩莉[1] 吴标[1] 赵福成[1] 王珍 刘振洲 REN Wei-hua;JIA Kui;LIU Cai-li;WU Biao;ZHAO Fu-cheng;WANG Zhen;LIU Zhen-zhou(The First Affiliated Hospital of Xinxiang Medical College,Weihui,Henan,China,453100)

机构地区：[1]新乡医学院第一附属医院

出　　处：《河南中医》2019年第9期1395-1398,共4页Henan Traditional Chinese Medicine

基　　金：河南省中医药科学研究专项课题项目(2014ZY02089)

摘　　要：目的:观察中风解郁汤治疗脑卒中后抑郁(post-stroke depression,PSD)的临床疗效。方法:将100例PSD患者按照随机数字表法分为对照组和治疗组各50例,对照组在神经内科常规药物治疗的基础上给予盐酸氟西汀胶囊,治疗组在神经内科常规药物治疗的基础上加用中风解郁汤,两组均以4周为1个疗程,共治疗2个疗程,观察汉密尔顿抑郁量表(HAMD)评分、白细胞介素-10(interleukin-10,IL-10)、白细胞介素-23(interleukin-23,IL-23)水平变化情况及药物不良反应。结果:对照组有效率为80.0%,治疗组有效率为90.0%,两组有效率比较,差异无统计学意义(P>0.05);两组PSD患者治疗前HAMD评分比较,差异无统计学意义(P>0.05),治疗组治疗8周后与对照组同期比较,差异有统计学意义(P<0.05);治疗组治疗8周后IL-10、IL-23含量与对照组比较,差异有统计学意义(P<0.05);对照组不良反应发生率为96.0%,治疗组不良反应发生率为28.0%,两组不良反应发生率比较,差异有统计学意义(P<0.05)。结论:中风解郁汤治疗脑卒中后抑郁可降低IL-10、IL-23水平,改善临床症状,且不良反应较低。Objective: To observe the clinical curative effect of Decoction for Relieving Stroke and Depression on Post-stroke Depression(PSD). Methods: A total of 100 patients with PSD were divided into the control group and the treatment group according to random number table method, with 50 cases in each group. The control group was treated with Fluoxetine Hydrochloride Capsules on the basis of routine drug treatment in neurology department, and the treatment group was treated with Decoction for Relieving Stroke and Depression on the basis of routine drug treatment in neurology department. Both groups were treated with 4 weeks as a course, and the treatment lasted for 2 courses totally. Then the changes of Hamilton Depression Scale(HAMD), interleukin-10(IL-10), interleukin-23(IL-23) and adverse drug reactions were observed. Results: The effective rate was 80.0% in the control group and 90.0% in the treatment group. There was no significant difference between the two groups(P>0.05). There was no significant difference in HAMD score between the two groups before treatment(P>0.05). There was significant difference in HAMD score between the treatment group and the control group after 8 weeks of treatment(P<0.05). After 8 weeks of treatment, the differences in the levels of IL-10 and IL-23 were statistically significant between the two groups(P<0.05). The incidence of adverse reactions was 96.0% in the control group and 28.0% in the treatment group. There was significant difference between the two groups(P<0.05). Conclusion: Decoction for Relieving Stroke and Depression has a remarkable efficacy on PSD, can improve the levels of IL-10 and IL-23, and clinical symptoms, and have low adverse reactions.

关 键 词：脑卒中 抑郁 中风解郁汤 盐酸氟西汀胶囊 

分 类 号：R259.433[医药卫生—中西医结合]