葛根、杜仲和淫羊藿对去势大鼠增加骨密度实验研究  

The Mixture of Pueraria Lobata,Eucommia,and Epimedium Increases Bone Mineral Density of Ovariectomized Female Rats

作　　者：段雨劼 聂焱[1] 吴媛妮 胡余明[1] DUAN Yujie;NIE Yan;WU Yuanni;HU Yuming(Hunan Center for Disease Control and Prevention,Changsha 410005,Hunan Province,China)

机构地区：[1]湖南省疾病预防控制中心,长沙410005

出　　处：《预防医学情报杂志》2019年第9期1068-1071,共4页Journal of Preventive Medicine Information

摘　　要：目的研究葛根、杜仲和淫羊藿混合物对去势大鼠增加骨密度的作用。方法雌性大鼠随机分为6组,建立去势大鼠致骨质疏松症模型。连续灌胃90 d后,检测股骨重量和长度、中心和远心端骨密度、骨钙含量。结果溶剂对照组大鼠的股骨骨密度及骨钙含量显著低于假手术组,成功建立去势大鼠致骨质疏松症模型;各剂量组与溶剂对照组比较,股骨重量、股骨长度差异均无统计学意义;高剂量组大鼠的股骨中心及远心端骨密度、股骨钙含量显著高于溶剂对照组(P<0.05),且不低于相应剂量的碳酸钙对照组,其他指标(体重除外)不显著低于溶剂对照组。结论葛根、杜仲和淫羊藿混合物具有增加去势大鼠骨密度的功能。Objective To study the effects of the mixture of pueraria lobata, eucommia, and epimedium on increasing ovariectomized rats’ bone mineral density. Methods Female rats were randomly divided into six groups, the osteoporosis model induced by ovariectomy in rats was established. After continuous gavage for 90 days, the weight, length, central and distal bone mineral density and calcium content of the femur were measured. Results The bone mineral density and bone calcium content of the solvent control group were significantly lower than that of the sham operation group,indicating successful establishment of osteoporosis model. Compared with the solvent control group, the weight and length of the femur had no statistical difference in each of dose groups. Whereas calcium content, central and distal bone density of femur in the high dose group were significantly higher than that in the solvent control group(P<0.05), and were not lower than that in the calcium carbonate control group. Other indicators in the high dose group,except for body weight, were not significantly lower than those in the solvent control group.Conclusion The mixture of pueraria lobata,eucommia, and epimedium could increase bone mineral density of ovariectomized rats.

关 键 词：葛根 杜仲 淫羊藿 骨密度 骨钙 绝经后骨质疏松症 

分 类 号：R944.9[医药卫生—药剂学]