^13C呼吸试验与粪便抗原检测试验对儿童幽门螺杆菌感染的诊断价值  

Diagnostic value of ^13 C respiratory test and fecal antigen test in children with Helicobacter pylori infection

作　　者：王沁芳[1] Wang Qinfang(Department of Gastroenterology,Shanxi Provincial Childrens Hospital,Taiyuan 030001,China)

机构地区：[1]山西省儿童医院消化科,太原030001

出　　处：《中国实用医刊》2019年第16期26-29,共4页Chinese Journal of Practical Medicine

摘　　要：目的分析^13C呼吸试验和粪便抗原检测试验对儿童幽门螺杆菌(Hp)感染的诊断价值.方法选取2017年2月至2019年1月山西省儿童医院消化内科以上消化道症状就诊的患儿66例,均行幽门螺杆菌粪便抗原试验(HpSA)、^13C尿素呼吸试验(^13C-UBT)检测,并接受胃镜检查对其进行确诊.统计66例患儿Hp感染情况,分析HpSA及^13C-UBT诊断效能.结果66例患儿经胃镜检查确诊Hp阳性27例,Hp阴性38例,不确定1例.1例不确定者排除于诊断效能研究,即65例患儿进入诊断效能分析.HpSA检测对65例患儿Hp感染的诊断敏感率为77.78%(21/27),特异度为92.11%(35/38),诊断准确率为86.15%(56/65).^13C-UBT断敏感率为96.30%(26/27),特异度为89.47%(34/38),诊断准确率为92.31%(60/65).^13C-UBT对Hp感染的诊断敏感率高于HpSA,差异有统计学意义(χ^2=4.103,P=0.043).结论^13C-UBT检测结果可有效反映患儿胃内Hp状况,其特异度和敏感度较高.HpSA检测具有操作简便的优势,可作为^13C-UBT的辅助替代方案.Objective To analyze the diagnostic value of 13C respiratory test and fecal antigen test in children with Helicobacter pylori ( Hp ) infection. Methods Sixty-six children with gastrointestinal symptoms in the Department of Gastroenterology in Shanxi Provincial Children 's Hospital from February 2017 to January 2019 were selected. All patients underwent Hp fecal antigen test ( HpSA) and 13C urea breath test (^13 C-UBT). A gastroscopy was performed to confirm the diagnosis. Statistics of Hp infection in 66 children were analyzed and the diagnostic efficacy of HpSA and 13C-UBT was analyzed. Results Thirty-six patients were diagnosed as Hp-positive in 27 cases by gastroscopy, and Hp-negative in 38 cases, not sure for one case. One case of uncertainty was excluded from the diagnostic efficacy study, so that, 65 patients entered the diagnostic efficacy analysis. The diagnostic sensitivity of HpSA to Hp infection in 65 patients was 77. 78%( 21/27 ), the specificity was 92. 11%( 35/38 ), and the diagnostic accuracy was 86. 15%(56/65). The 13C-UBT susceptibility rate was 96. 30%(26/27), the specificity was 89. 47%( 34/38 ), and the diagnostic accuracy was 92. 31%( 60/65 ). The sensitivity of^13 C-UBT to Hp infection was higher than that of HpSA, and the difference was significant (χ^2 =4. 103, P=0. 043). Conclusions The results of13C-UBT test can effectively reflect the Hp status in the stomach of children, and its specificity and sensitivity are high. HpSA detection has the advantage of easy operation, moreover, it can be used as an auxiliary alternative to^13 C-UBT.

关 键 词：幽门螺杆菌感染 儿童 粪便抗原检测试验 ^13C呼吸试验 

分 类 号：R725.7[医药卫生—儿科]