妊娠妇女甲状腺功能血清指标参考值的建立  

Establishment of Reference Value of Thyroid Function Serum Index Among Pregnant Women in Tianjin Binhai New District

作　　者：陈兴国[1] 李庆欣[1] 李芳[1] 屈年伟 张贺平[2] 李玉艳[3] Chen Xingguo;Li Qingxin;Li Fang(Tianjin TEDA Hospital, Tianjin 300451 ,China)

机构地区：[1]天津市泰达医院,天津300451 [2]天津市第五中心医院 [3]天津市汉沽医院

出　　处：《医学新知》2019年第4期380-381,共2页New Medicine

摘　　要：目的建立滨海新区孕妇甲状腺功能指标的参考值,为临床妊娠期妇女甲状腺疾病的诊治提供可靠的实验室依据.方法采集2013年1 月至2016 年6 月在滨海新区泰达医院、五中心医院、汉沽医院的613例不同孕龄的妊娠妇女的血清,应用化学发光法测定血清游离甲状腺素(FT4 )及促甲状腺(TSH)水平,并应用中位数及95%可信区间统计方法建立妊娠期特异性血清FT4 及TSH正常参考值范围.结果滨海新区不同孕龄孕妇的甲状腺功能的正常参考区间:妊娠早期(妊娠1~12周):FT4 10.51 ~19.05 pmol/L,TSH 0.02~3.41 mIU/L;妊娠中期(妊娠13 ~27 周):FT4 9.84 ~19.29 pmol/L,TSH 0.03 ~3.76 mIU/L;妊娠晚期(妊娠28~40周)FT4 7.39~13.25 pmol/L,TSH 0.50~9.48 mIU/L.结论妊娠期间,加强监测孕妇的甲状腺激素变化,并制定出妊娠期甲状腺激素的正常参考值范围,为妊娠期甲状腺疾病的诊治提供了临床数据,将对及时诊断和治疗本地区妊娠甲状腺功能异常起到一定的参考作用.Objective To establish the reference value of thyroid function serum indexes of pregnant women in Binhai New Area,and to provide reliable laboratory evidence for the diagnosis and treatment of thyroid diseases in pregnant women.Methods Serum of 613 pregnant women with different gestational age in TEDA Hospital,the Fifth Central Hospital and Hangu Hospital were collected from Jan.2013 to Jun.2016.Serum free thyroxine(FT4)and thy﹣roid-stimulating hormone(TSH)levels were measured by chemiluminescence.The pregnancy specific serum FT4 and TSH in the normal reference value was estimated by the median value and 95% confidence interval.Results The normal reference ranges of thyroid function of pregnant women with different gestational age in Binhai District were as follows:first trimester(pregnancy 1 ~12 weeks),FT4 10.51 ~19.05 pmol/L,TSH 0.02 ~3.41 mIU/L;second tri﹣mester(pregnancy 13~27 weeks),FT4 9.84 ~19.29 pmol/L,TSH 0.03 ~3.76 mIU/L;last trimester(28 ~40 weeks of pregnancy),FT4 7.39~13.25 pmol/L,TSH 0.50~9.48 mIU/L.Conclusion Monitoring changes of thy﹣roid hormones and setting up normal reference range of thyroid hormone during pregnancy can provide clinical data for diagnosis and treatment of thyroid disease,which will play a certain role in the timely diagnosis and treatment of thy﹣roid dysfunction in local area.

关 键 词：妊娠 参考值范围 甲状腺激素 

分 类 号：R581[医药卫生—内分泌]