接受HAART治疗HIV感染/艾滋病成年男性患者精液质量的研究  

Study on in HHIV/AIDS patients undergoing HAART

作　　者：朱郇荣[1] 范立新[1] 李宝金 杨柳平[1] 李凌华[2] Zhu xunrong;Fan lixin;Li baojin;Yang liuping;Li linghua(Department of Urology,Guangzhou Eighth People's Hospital;Department of Infectious Disease,Guangzhou Eighth Peopled Hospital Guangzhou 510070,China;Department of Surgery,Guangzhou Eighth People's Hospital)

机构地区：[1]广州市第八人民医院泌尿科,广东广州510070 [2]广州市第八人民医院感染科,广东广州510070 [3]广州市第八人医院外科,广东广州510070

出　　处：《中国男科学杂志》2019年第4期35-38,共4页Chinese Journal of Andrology

基　　金：十三五国家科技重大专项课题(编号:20182X10302103-002);2016广东省医学科学技术研究基金项目(编号:A2016462)

摘　　要：目的了解人类免疫缺陷病毒(HIV)感染/艾滋病(AIDS)成年男性患者接受高效联合抗逆转录病毒治疗(HAART)后的精液质量,以指导其优生优育。方法以34例接受HAART至少6个月的HIV阳性成年男性患者为研究对象(试验组),检测其精液精子密度、活率、活力、畸形率、精浆中性α-葡糖苷酶、支原体、过氧化物酶及HIV-1RNA载量。另外随机选择50例HIV阴性成年男性为对照(对照组)。结果试验组和对照组年龄分别为24~40岁(31±5)与26~40岁(29±4),无明显差异(P=0.253)。试验组接受基线CD4计数220~965(390±180),接受HAART6~48个月(18±10),治疗后外周血HIV-1RNA载量均小于20拷贝copies/mL,CD4计数341-1058(534+190),除3例精液HIV-1RNA载量分别为72,47及221copies/mL,其他均小于20copies/mL。与对照组比较,试验组精子活力和前向运动精子百分率降低(P=0.000),精浆中性α-葡糖苷酶亦降低(χ^2=13.21,P<0.01),而其他指标显差异无统计学意义。结论HIV感染/AIDS患者经过HAART治疗后,其精子活力仍低于正常人。Objective To investigate the quality of semen ofHIV/AIDS patients after highly active antiretroviral therapy (HAART) treatment for guiding their eugenics and nurture. Methods Semen were collected from 50 healthy adult males and 34 HIV/AIDS males who had received HAART for more than 6 months, Then routine semen parameters, neutral α-glucocytase, mycoplasma and peroxidase, and semen RNA load were measured and the the possible influence related to semen quality were evaluated. Results The total sperm motility and forward motility in HIV/AIDS patient were decreased, the neutral α-glucoside of 11 cases in 28 patients with low total sperm vitality was reduced, neutral α-glucoside of 12 cases in 32 patients with the low forward movement was also reduced(χ^2 =13.21 ,P<0.01). Conclusion After treatment with HAART in HIV/AIDS patients, their semen vitality is still not improved significantly improved, which may be related to the damage of epididymal epithelial cells caused by HAART drugs.

关 键 词：HIV感染 获得性免疫缺陷综合征 高效联合抗逆转录病毒治疗 精子能动性 精浆中性α-葡糖苷酶 

分 类 号：R512.91[医药卫生—内科学]