芎芍胶囊对动脉粥样硬化模型兔血脂和超敏C反应蛋白的影响  

Influence of Xiongshao Capsule on Serum Lipid and hs-CRP in Rabbits with Atherosclerosis

作　　者：盛松 徐凤芹[1] 张艳虹[1] SHENG Song;XU Fengqin;ZHANG Yanhong(Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China)

机构地区：[1]中国中医科学院西苑医院

出　　处：《中西医结合心脑血管病杂志》2019年第17期2595-2598,共4页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：国家自然科学基金资助项目(No.81173385)

摘　　要：目的观察芎芍胶囊对高脂饮食致兔动脉粥样硬化(AS)模型血脂水平和超敏C反应蛋白(hs-CRP)的影响,探讨其抗AS的机制。方法将60只雄性新西兰大耳兔随机分为对照组、模型组、芎芍胶囊小剂量组(小剂量组)、芎芍胶囊中剂量组(中剂量组)、芎芍胶囊大剂量组(大剂量组)、辛伐他汀组,每组10只,除对照组外均采用高脂饲料喂养复制兔AS模型,连续14周。于造模前及第6周、12周、14周时从耳缘静脉取血测定总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、载脂蛋白AⅠ(ApoAⅠ)、载脂蛋白B100(ApoB100)、hs-CRP,比较各组血脂水平和hs-CRP变化。结果6周及12周时,各用药组血脂指标与模型组比较差异无统计学意义(P>0.05);14周时,各用药组HDL与模型组比较差异无统计学意义(P>0.05),小剂量组、中剂量组、辛伐他汀组TC、LDL较模型组降低(P<0.05或P<0.01),小剂量组TC低于大剂量组(P<0.05),中剂量组、辛伐他汀组LDL低于大剂量组(P<0.05),各用药组ApoAⅠ、ApoB100、hs-CRP较模型组下降(P<0.05或P<0.01)。结论芎芍胶囊可降低TC、LDL、ApoB100、hs-CRP,芎芍胶囊可能通过调节血脂、抗炎发挥抗AS作用。Objective To investigate the effects of Xiongshao Capsule(XSC)on serum lipid and high-sensitivity C-reactive protein(hs-CRP)in rabbits with atherosclerosis.Methods Sixty male New Zealand rabbits were randomly divided into 6 groups:control group,model group,the low-dose XSC group,medium-dose XSC group,high-dose XSC group,and simvastatin group.Except control group,all the rabbits were fed by high-fat diet for 14 weeks to copy atherosclerosis model.The blood samples were drawn from auricular veins before the experiment and on the 6 th,12 th as well as 14 th weeks to test total cholesterol(TC),triacylglycerol(TG),high-density lipoprotein(HDL),low density lipoprotein(LDL),ApoA,ApoB100 and hs-CRP.Results There was no significant difference between the model group and the four drug groups of lipid indexes on the 6 th and 12 th weeks(P>0.05).There was no significant difference between the model group and the four drug groups of HDL level on the 14 th weeks(P>0.05).Compared with the model group,the ApoAⅠ,TC,and,LDL levels were lower in the low-dose XSC group,medium-dose XSC group,and simvastatin group(P<0.05 or P<0.01).The TC level in the low-dose XSC group was lower than that in the high-dose XSC group(P<0.05).The LDL level in the medium-dose XSC group and simvastatin group were lower than that in the high-dose XSC group(P<0.05).The ApoB100 and hs-CRP levels in four drug groups were lower than those in the model group(P<0.05 or P<0.01).Conclusion XSC can reduce TC,LDL,ApoB100,and hs-CRP levels,it probably plays a role in anti-atherosclerosis through serum lipid regulation and anti-inflammation effect.

关 键 词：动脉粥样硬化 芎芍胶囊 血脂 炎症因子 超敏C反应蛋白 

分 类 号：R541[医药卫生—心血管疾病] R285.5[医药卫生—内科学]