细辛脑注射液对中度AECOPD患者临床症状和HIF-1α的影响研究  

Study on the effects of asarone injection on clinical symptoms and HIF-1α in patients with moderate AECOPD

作　　者：向承忠 向勇 谭长友 张维[2] XIANG Chengzhong;XIANG Yong;TAN Changyou;ZHANG Wei(Respiratory Medicine,the First People′s Hospital of Wanzhou District,Chongqing 404040,China;Respiratory Medicine,the First Affiliated Hospital of Chengdu Medical College,Chengdu,Sichuan 610500,China)

机构地区：[1]重庆市万州区第一人民医院呼吸内科,404040 [2]成都医学院第一附属医院呼吸内科,四川成都610500

出　　处：《现代医药卫生》2019年第19期2932-2935,共4页Journal of Modern Medicine & Health

基　　金：国家自然科学基金青年科学基金项目(81600388)

摘　　要：目的探讨细辛脑注射液对于中度慢性阻塞性肺疾病急性加重期(AECOPD)患者肺功能、气道炎症及血单核细胞人低氧诱导因子1α(HIF-1α)水平的影响。方法将2017年12月至2018年12月重庆市万州区第一人民医院收治的120例中度AECOPD患者随机平均分为对照组(常规治疗)和观察组(细辛脑注射液+常规治疗),每组60例。在治疗0、5d时记录患者动脉血气分析结果[动脉血氧分压(PaO2)、动脉二氧化碳分压(PaCO2)、pH];酶联免疫吸附试验(ELISA)分析血中肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)和IL-6水平;使用肺功能仪记录患者第1秒用力呼气容积占预计值百分比(FEV1%);使用Westernblotting检测血单核细胞HIF-1α水平。结果治疗5d后,2组患者血中TNF-α、IL-1和IL-6水平、血单核细胞HIF-1α水平、血气分析结果(PaO2、PaCO2、pH值)和FEV1占预计值%均较治疗前明显改善,且观察组各指标较对照组改善更加明显,差异均有统计学意义(P<0.05)。在治疗期间未见明显与细辛脑注射液相关的严重不良反应。结论细辛脑注射液可通过抑制单核细胞HIF-1α的表达减轻气道炎症水平,改善患者的肺功能,这为细辛脑广泛应用于AECOPD的临床治疗提供了进一步的依据。Objective To investigate the effects of asarone injection on lung function,airway inflammation,and blood monocyte human HIF-αlevels in patients with AECOPD.Methods In the current investigation,120 patients with moderate AECOPD admitted to the First People′s Hospital of Wanzhou District from December 2017 to December 2018 were randomly divided into control group(regular treatment)and observation group(asarone injection+regular treatment),with 60 in each.Before and after 5 days interventions,air blood gas(ABG)indexes(PaO 2,PaCO 2 and pH)were recorded,the serum levels of TNF-α,IL-1,and IL-6 were measured by ELISA;the level of HIF-1αin blood monocytes were analyzed by western blotting;lung functions(FEV 1%)was also recorded.Results After 5 days treatments,the serum levels of TNF-α,IL-1,and IL-6,the level of HIF-1αin blood monocytes,and FEV 1%were all improved in both groups,and the improvement in treatment group was more noticeable than control group,the differences were statistically significant(P<0.05).Then,no serious adverse reactions related to asarone injection were observed in study period.Conclusion Asarone injection is a valuable and useful drug for the treatment of AECOPD probably via the down-regulation of HIF-1αexpression in monocytes.

关 键 词：细辛 注射剂 肺疾病 慢性阻塞性 慢性阻塞性肺疾病急性加重期 血气分析 肺功能 HIF-1Α 

分 类 号：R563[医药卫生—呼吸系统]