质谱成像在脑神经科学中的应用进展  

Progress of Mass Spectrometry Imaging in Neuroscience

作　　者：黄熹 刘会会[1,2] 毛兰群 熊彩侨[1,2] 聂宗秀 HUANG Xi;LIU Hui-Hui;MAO Lan-Qun;XIONG Cai-Qiao;NIE Zong-Xiu(Beijing National Laboratory for Molecular Sciences,Key Laboratory of Analytical Chemistry for Living Biosystems,Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院化学研究所,中国科学院活体分析化学重点实验室,北京分子科学国家实验室,北京100190 [2]中国科学院大学,北京100049

出　　处：《分析化学》2019年第10期1592-1600,共9页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(Nos.21790390,21790392,21625504)资助~~

摘　　要：大脑是人体内功能最复杂、结构最精细的器官。脑内的化学物质种类众多,含量迥异,分布不一,对这些重要分子进行分析表征一直颇具挑战性。质谱成像是一种具有高灵敏、免标记、化学专一性且可同时监测多种分子空间分布的新兴成像技术。质谱成像已广泛应用于神经退行性疾病、中枢神经肿瘤及脑中药代动力学的研究。本文简要介绍了质谱成像方法的基本原理和重要技术进展,并着重讨论了近年来质谱成像在上述脑神经科学领域中的代表性应用。Brain is the central organ of the human nervous system with complex functionality and complicated structure.The chemicals in brain play important roles in metabolism and signal transduction.It is a challenge for scientists to characterize and analyze these chemicals due to their diversity in chemical property and concentration.Mass spectrometry imaging as a new technique is able to screen the spatial distribution of various molecules simultaneously without labeling and has been broadly applied in the study of neurodegenerative disease,brain tumor and pharmacokinetic in brain.This review introduces the principle and new technique of mass spectrometry imaging,and focuses on its typical applications in neuroscience published in recent years.

关 键 词：质谱成像 脑神经科学 基质辅助激光解吸电离 解吸电喷雾电离 评述 

分 类 号：O657.63[理学—分析化学] R741.04[理学—化学]