线粒体与卵子老化  

Mitochondria and oocyte aging

作　　者：刘晓娉 黄睿[1] LIU Xiao-ping;HUANG Rui(Reproductive Medicine Research Center,the Sixth Affiliated Hospital of Sun Yat-sen University,Guangzhou510655)

机构地区：[1]中山大学附属第六医院生殖医学研究中心

出　　处：《生殖医学杂志》2019年第10期1120-1124,共5页Journal of Reproductive Medicine

基　　金：国家重点研发项目(2016YFC1000302)

摘　　要：线粒体异常是卵子老化的重要原因。线粒体移植技术有望成为改善卵子质量和胚胎发育潜能及提高辅助生殖助孕成功率的新方法。本文就线粒体与卵子质量的关系、线粒体移植在辅助生殖领域的发展历史及其可能的作用机制等方面进行综述。Mitochondrial abnormality is the main cause of oocyte aging.Mitochondrial transfer technology is expected to be a novel treatment to improve the oocyte quality and the potential of embryo development,as well as increase the pregnancy rate of assisted reproductive technology.This paper reviews the relationship between mitochondria and the quality of oocyte,the development history of mitochondrial transfer treatment in the field of assisted reproduction and its possible mechanisms of improving the quality of oocyte.

关 键 词：卵子老化 线粒体移植 卵子质量 辅助生殖 

分 类 号：R711.6[医药卫生—妇产科学]