失眠症患者认知功能损害的特点及其机制  

Insomnia: the characteristics and mechanisms of cognitive impairment

作　　者：何静文[1] 屠志浩 苏彤[1] 肖磊 唐云翔[1] HE Jing-wen;TU Zhi-hao;SU Tong;XIAO Lei;TANG Yun-xiang(Department of Medical Psychology, Faculty of Psychology, Naval Medical University (Second Military Medical University),Shanghai 200433, China;Department of Nautical Psychology, Faculty of Psychology, Naval Medical University (Second Military Medical University),Shanghai 200433, China)

机构地区：[1]海军军医大学(第二军医大学)心理系医学心理学教研室,上海200433 [2]海军军医大学(第二军医大学)心理系航海心理学教研室,上海200433

出　　处：《第二军医大学学报》2019年第9期1015-1019,共5页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金(81372122);军队“十二五”重大项目(AWS13J003,AWS12J003);全军军事科研“十二五”计划(13QJ003-005);全军心理卫生应用型科研课题重点项目(12XLZ109)~~

摘　　要：失眠症是常见的睡眠障碍之一,患者常伴有严重的主观认知功能障碍,但客观认知功能测试显示他们并不存在明显的认知功能损害。神经影像、神经生物化学和神经电生理学等方面的研究提示,失眠症患者可能存在潜在的认知功能损害的客观证据。本文对失眠症患者的认知功能损害特点进行阐述,并介绍在神经影像、神经生物化学和神经电生理学等方面潜在的认知功能损害的证据,分析其可能的原因。Insomnia is one of the common sleep disorders. Despite of wide recognition that patients with insomnia subjectively experience impaired daytime functioning, there is little consistent objective evidence of neurobehavioural performance deficits. However, evidences of potential cognitive impairment in insomnia patients have been found in neuroimaging, neurobiochemistry and neuroelectrophysiology. This paper describes the characteristics of cognitive impairment in insomnia patients, then introduces the evidence of potential cognitive impairment found in neuroimaging, neurobiochemistry and neuroelectrophysiology, and finally analyzes the possible causes of this phenomenon.

关 键 词：入睡和睡眠障碍 认知 神经影像 神经生物化学 神经电生理学 

分 类 号：R338.63[医药卫生—人体生理学] R395[医药卫生—基础医学]