噬菌体控制主要肠杆菌感染的研究进展  

Advances in Phage Therapy for Controlling Enterobacteriaceae Infection

作　　者：任宏宇 李振[2,3] 李晓宇 耿慧君[1] 王丽丽 李淑英 徐永平[1,2,4,5] Ren Hong-yu;Li Zhen;Li Xiao-yu;Geng Hui-jun;Wang Li-li;Li Shu-ying;Xu Yong-ping(School of Bioengineering,Dalian University of Technology,Dalian 116024;Center for Food Safety of Animal Origin,Ministry of Education,Dalian 116600;School of Ocean and Biological Engineering,Yancheng Institute of Technology,Yancheng 224051;Dalian SEM Bio-Engineering Technology Co.Ltd,Dalian 116620;Center for Phage Applied Engineering Technology of Dalian SEM,Liaoning Province,Dalian 116600)

机构地区：[1]大连理工大学生物工程学院动物生物技术与营养研究室,大连116024 [2]教育部动物性食品安全保障技术工程研究中心,大连116600 [3]盐城工学院海洋与生物工程学院,盐城224051 [4]大连赛姆生物工程技术公司,大连116620 [5]辽宁省大连赛姆噬菌体应用工程技术研究中心,大连116600

出　　处：《国外医药（抗生素分册）》2019年第5期430-435,共6页World Notes on Antibiotics

摘　　要：肠杆菌科病原菌是临床上分离量最高的细菌,常引起肠道、腹腔、泌尿道、生殖道和呼吸道等多种感染,临床治疗通常以抗生素为主。然而,随着抗生素的广泛使用,在肠杆菌科产生了大量的耐药性菌株,对临床治疗带来了极大地困扰。如今,肠杆菌科细菌的耐药问题越来越引起世界医疗卫生机构的关注与重视,相关研究人员开始致力于寻找并开发能够替代抗生素的治疗方式,其中,噬菌体作为一种天然抗菌生物,再次成为人们关注的热点。本文就我国临床上分离量最高的三种肠杆菌(大肠埃希菌、肺炎克雷伯菌和阴沟肠杆菌)的噬菌体治疗进行总结,阐述噬菌体在控制主要肠杆菌感染的相关研究进展。The Enterobacteriaceae are the most clinically isolated bacteria,often causing intestinal infections,abdominal infections,urinary tract infections,genital tract infections and respiratory tract infections and other infections,and the main clinical treatment is antibiotics.However,with the extensive use of antibiotics,a large amount of drug-resistant Enterobacteriaceae bacteria have been created,greatly disturbing the clinical treatment.Nowadays,the drug resistance of Enterobacteriaceae is getting more and more attention from the world’s medical and health institutions.Many researchers and institutions begin to devote themselves to finding and developing better ways to replace antibiotics.Phage,as a kind of natural antibacterial organisms,become the focus of attention again.In this paper,the progress of phage therapy of the three clinical isolates of Enterobacteriaceae(Escherichia coli,Klebsiella pneumoniae and Enterobacter cloacae),which have the highest clinical isolates in China,are reviewed.

关 键 词：噬箘体 肠杆菌感染 噬箘体疗法 细菌耐药性 

分 类 号：R978.19[医药卫生—药品]