应用噬菌体治疗畜禽细菌性腹泻的研究进展  

Research Progress on the Application of Bacteriophages for Control of Animal Bacterial Diarrhea

作　　者：王通[1] 李晓宇[1,2,4] 王丽丽 李淑英[2,3,4] 徐永平[1,2,3,4] Wang Tong;Li Xiao-yu;Wang Li-li;Li Shu-ying;Xu Yong-ping(School of Bioengineering,Dalian University of Technology,Dalian 116024;Center for Food Safety of Animal Origin,Ministry of Education,Dalian 116600;Dalian SEM Bio-Engineering Technology Co. Ltd,Dalian 116620;Center for Phage Applied Engineering Technology of Dalian SEM,Liaoning Province,Dalian 116600)

机构地区：[1]大连理工大学生物工程学院,大连116024 [2]动物性食品安全保障技术教育部工程研究中心,大连116600 [3]大连赛姆生物工程技术公司,大连116620 [4]辽宁省大连赛姆噬菌体应用工程技术研究中心,大连116600

出　　处：《国外医药（抗生素分册）》2019年第5期436-440,共5页World Notes on Antibiotics

摘　　要：近年来国内养殖产业发展迅速。由大肠埃希菌、沙门菌等致病菌引起的畜禽肠道疾病,常伴有不同程度的腹泻,影响动物的生长发育,严重时可导致死亡,给养殖业造成严重的经济损失。过量使用抗生素使致病菌产生了耐药性,并引起了动物体内和动物制品中药物残留等诸多问题。针对这一情况,噬菌体凭借其特异性高、不易造成抗性、生产成本较低等诸多优势,成为了一种潜在的理想的抗生素替代品。The domestic breeding industry developed rapidly in recent years.Diarrhea caused by pathogenic bacteria such as Escherichia coli and Salmonella influences the growth of animals and cause serious economic losses to aquaculture industry.Excessive use of antibiotics makes the pathogenic bacteria resistant,and brings many problems,such as drug residues in animal and animal products.In view of this situation,bacteriophage has become an ideal substitute for antibiotics because of its high specificity,low resistance and low production cost.

关 键 词：养殖业 大肠埃希菌 沙门菌 噬菌体 

分 类 号：R978.19[医药卫生—药品]