噬菌体在多重耐药菌创伤性感染治疗中的作用  

The Role of Phage in the Treatment of Superbugular Infections

作　　者：褚国煜 李晓宇[1,2,4] 王丽丽 李淑英[2,3,4] 徐永平[1,2,3,4] Chu Guo-yu;Li Xiao-yu;Wang Li-li;Li Shu-ying;Xu Yong-ping(School of Bioengineering,Dalian University of Technology,Dalian 116024;Center for Food Safety of Animal Origin,Ministry of Education,Dalian 116600;Dalian SEM Bio-Engineering Technology Co. Ltd,Dalian 116620;Center for Phage Applied Engineering Technology of Dalian SEM,Liaoning Province,Dalian 116600)

机构地区：[1]大连理工大学生物工程学院,大连116024 [2]教育部动物性食品安全保障技术工程研究中心,大连116600 [3]大连赛姆生物工程技术公司,大连116620 [4]辽宁省大连赛姆噬菌体应用工程技术研究中心,大连116600

出　　处：《国外医药（抗生素分册）》2019年第5期441-444,共4页World Notes on Antibiotics

摘　　要：细菌的抗生素耐药性日渐成为人类生存的一大威胁。抗生素在人类和动植物中的过度使用,使细菌的耐药性由单一的发展成多重的。目前常用的抗生素已经无法抑制多重耐药菌的生长繁殖。新型药物的开发需要的周期较长,投入成本高,因此噬菌体治疗再次得到学者们的关注。目前,在美国已有一例通过静脉施用噬菌体联合抗生素治愈多重耐药的鲍曼不动杆菌的成功案例,为噬菌体治疗开辟了新思路。The antibiotic resistance of bacteria has gradually become a major threat to human survival.The excessive use of antibiotics in humans and plant and animal species has allowed the development of bacterial resistance to from multiple sources.The commonly used antibiotics have not been able to inhibit the growth and reproduction of multi-drug resistant bacteria.The development of new drugs requires a long period of time and high input costs,so phage treatment has once again received the attention of scholars.At present,in the United States,there has been one case of successful treatment of multi-drug-resistant strains of Acinetobacter baumannii by intravenous administration of bacteriophage combined with antibiotics.It provides new ideas for bacteriophage therapy.

关 键 词：多重耐药细菌 噬菌体 抗生素 耐药性 

分 类 号：R978.19[医药卫生—药品]