阿司匹林、立普妥联合口服治疗不同类型颈动脉斑块患者的疗效观察  

Effect of oral administration of aspirin and lipitor in combination for patients with different types of carotid plaques

作　　者：王明琦[1] 黄凌燕 陈琳 WANG Mingqi;HUANG Lingyan;CHEN Lin(Ganzhou People′s Hospital in Jiangxi Province,Ganzhou,Jiangxi,341000)

机构地区：[1]江西省赣州市人民医院

出　　处：《实用临床医药杂志》2019年第17期39-41,共3页Journal of Clinical Medicine in Practice

摘　　要：目的探讨联合口服阿司匹林与立普妥对不同类型颈动脉斑块的疗效。方法将本院80例颈动脉斑块患者分为软斑组45例、混合型斑组16例和硬斑组19例,均给予联合口服阿司匹林与立普妥。对比3组患者治疗前,治疗6、12个月时斑块大小、血清炎性指标及血脂变化。结果与治疗前比较,治疗6、12个月时软斑组、混合性斑块组斑块均显著缩小(P<0.05),且治疗12个月时效果显著优于6个月时,但硬斑组斑块大小无显著变化(P>0.05);与治疗前相比,治疗6、12个月时3组患者血清超敏C反应蛋白(hs-CRP)、血浆总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)均显著降低,但高密度脂蛋白(HDL-C)显著上升(P<0.05),且治疗12个月时效果显著优于6个月时。结论联合口服阿司匹林与立普妥可以显著缩小颈动脉软斑块与混合型斑块,改善患者血清炎性反应、血脂水平,但对硬斑块治疗效果不显著。Objective To investigate the effect of oral administration of aspirin and lipitor in combination for patients with different types of carotid plaques.Methods A total of 80 patients with carotid artery plaques in our hospital were divided into soft plaque group ( n =45),mixed type plaque group( n =16)and hard plaque group ( n =19).Patients of three groups were given oral administration of aspirin and lipitor in combination.The plaque size,serum inflammatory index and blood lipid of the three group before treatment and 6,12 months after treatment were compared.Results Compared with before treatment,soft plaque group and mixed plaque group were significantly smaller at 6 and 12 months after treatment ( P <0.05),and the outcomes at 12 months was better than at 6 months,but the size of hard plaque group has no obvious change( P >0.05).Compared with before treatment,the serum hypersensitive C reactive protein (hs-CRP),plasma total cholesterol (TC),triglyceride (TG),low density lipoprotein cholesterol (LDL-C) at 6 and 12 months after treatment of three groups were significantly decreased,but high-density lipoprotein (HDL-C) was increased( P <0.05),and the results of at 12 months after treatment was better than that at 6 months after treatment.Conclusion Combined oral administration of aspirin and lipitor can significantly reduce the soft and mixed type of carotid artery plaques,and it can improve patients′serum inflammatory reaction and lipid levels,but the effect of hard plaques treatment is not obvious.

关 键 词：颈动脉斑块 阿司匹林 立普妥 血清指标 颈动脉内膜中层厚度 斑块面积 

分 类 号：R543.5[医药卫生—心血管疾病]