富血小板血浆在骨修复中的机制及应用  

Mechanism and application of platelet-rich plasma in bone repair

作　　者：刘洋[1] 王文波[1] LIU Yang;WANG Wenbo(Third Department of Orthopedics,First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院骨三科

出　　处：《临床与病理杂志》2019年第9期2041-2046,共6页Journal of Clinical and Pathological Research

基　　金：黑龙江省自然科学基金(H201454);黑龙江省普通高等学校骨干教师创新能力资助计划(1054G028)~~

摘　　要：富血小板血浆(platelet-rich plasma,PRP)是含有高浓度血小板的血浆,其富含的各类生长因子,可在骨再生的各个阶段直接或间接促进干细胞向成骨分化,同时抑制破骨细胞分化,从而促进新骨再生。为阐述大段骨缺损后的骨修复过程,大量研究围绕成骨机制展开。Platelet-rich plasma is a plasma containing high concentrations of platelets, which are rich in various growth factors, which can directly or indirectly promote the differentiation of stem cells into osteoblasts at various stages of bone regeneration, and inhibit osteoclast differentiation, thereby promoting new bone regeneration. In order to explain the bone repair process after large segmental bone defect, a large number of studies have been carried out around the osteogenesis mechanism.

关 键 词：骨缺损 富血小板血浆 成骨机制 

分 类 号：R68[医药卫生—骨科学]