替比夫定对乙型肝炎孕妇免疫功能、新生儿乙型肝炎病毒(HBV)宫内感染率和阻断成功率的影响  

Influences of telbivudine on the immune function,the HBV intrauterine infection rate and the blocking success rate of the pregnant women with hepatitis B

作　　者：沈毅会 SHEN Yi-hui(Jilin Maternal and Child Health,Changchun 130061,China)

机构地区：[1]吉林省妇幼保健院

出　　处：《吉林医学》2019年第10期2211-2213,共3页Jilin Medical Journal

摘　　要：目的:研究和分析替比夫定对乙型肝炎孕妇免疫功能、新生儿乙型肝炎肝炎病毒(HBV)宫内感染率和阻断成功率的影响。方法:选取106乙型肝炎孕妇例作为研究对象,根据患者意愿将其分为研究组(n=63)和对照组(n=43)。研究组孕妇给予口服替比夫定治疗。对两组孕妇治疗前及分娩前的外周血HBV-DNA载量、T淋巴细胞亚群指标进行检测和比较,对两组新生儿的HBV宫内感染率、出生7个月时的HBV感染阻断成功率进行观察和比较,对两组孕妇用药不良反应、剖宫产率及妊娠并发症发生率进行观察和比较,对两组新生儿的孕周、体质量、出生1分钟Apgar评分进行观察和比较。结果:研究组孕妇治疗后的HBV-DNA载量较治疗前显著下降,T淋巴细胞亚群指标较治疗前显著改善,且均优于对照组,差异统计学意义(P<0.05),研究组新生儿的HBV宫内感染率显著低于对照组,出生后7个月时的HBV感染阻断成功率显著高于对照组,差异均有统计学意义(P<0.05)。结论:于孕晚期给予HBV-DNA载量较高的乙型肝炎孕妇口服替比夫定进行抗病毒治疗,能够显著改善患者的免疫功能、降低病毒载量和新生儿HBV宫内感染率、提高阻断成功率。Objective To study and analyze the influences of telbivudine on the immune function,the hepatitis B virus (HBV) intrauterine infection rate and the blocking success rate of the pregnant women with hepatitis B. Method 106 cases of pregnant women with hepatitis B were selected as the research subjects and divided into the study group (63 cases) and the control group (43 cases) according to the patient's wishes.The patients in the study group were treated with oral telbivudine.The HBV-DNA loads,the T lymphocytes subgroups indicators in the peripheral blood before the treatment and before delivery of the pregnant women in the two groups of were measured and compared.The HBV intrauterine infection rates and the blocking success rate for HBV infection at 7 months after birth of the newborns in the two groups were observed and compared.The adverse reactions,the rate of cesarean section and the incidence of pregnancy complications of the pregnant women in the two groups were observed and compared.The gestational weeks,the body weights and the Apgar scores at 1 minutes after birth the newborns in the two groups were observed and compared. Results The HBV-DNA load of the pregnant women in the study group decreased significantly compared with those before the treatment,the T lymphocytes subgroups indicators improved significantly compared with those before the treatment,which were better than those in the control group,the differences were statistically significant ( P <0.05).The HBV intrauterine infection rate of the newborns in the study group was significantly lower than that in the control group.The blocking success rate for HBV infection at 7 months after birth was significantly higher than that in the control group.The differences were statistically significant ( P <0.05). Conclusion In the late pregnancy,the application of the antiviral treatment of telbivudine for the pregnant women with hepatitis B who are with high HBV-DNA load can significantly improve the immune functions,reduce the viral load and the HBV intrau

关 键 词：替比夫定 乙型肝炎 肝炎肝炎病毒 孕妇 免疫功能 新生儿 

分 类 号：R714.251[医药卫生—妇产科学]