486例注射用七叶皂苷钠主动监测情况分析  

Analysis of Active Monitoring of 486 Cases of Sodium Aescinate for Injection

作　　者：张元萍 熊英[1] 季宏建[1,2] ZHANG Yuanping;XIONG Ying;JI Hongjian(Dept. of Pharmacy, the Affiliated Yancheng Hospital of Southeast Univesity Medical College, Jiangsu Yancheng 224001, China;College of Pharmacy, Nanjing University of Chinese Medicine , Jiangsu Nanjing 220023 , China)

机构地区：[1]东南大学医学院附属盐城医院药学部,江苏盐城224001 [2]南京中医药大学药学院,江苏南京220023

出　　处：《中国医院用药评价与分析》2019年第8期985-986,990,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:了解注射用七叶皂苷钠临床用药情况,为临床合理应用该药提供参考。方法:采用中国医院药物警戒系统(Chinese hospital pharmacovigilance system,CHPS)主动监测功能,检索2017年9月至2018年9月东南大学医学院附属盐城医院(以下简称"我院")486例使用注射用七叶皂苷钠患者的病历,对注射用七叶皂苷钠的使用情况进行统计分析,评价用药合理性。结果:486例使用注射用七叶皂苷钠的患者中,男性292例,女性194例;平均年龄53.62岁;原患疾病主要为骨折、外伤和静脉曲张;用药原因均为降低术后组织水肿或静脉回流障碍;378例患者用药剂量为10 mg,104例患者用药剂量为5 mg,4例患者用药剂量为20 mg;给药途径为静脉滴注或静脉注射;溶剂主要为0.9%氯化钠注射液或10%葡萄糖注射液。注射用七叶皂苷钠的不合理应用主要表现为溶剂量不适宜,共15例患者使用葡萄糖注射液或0.9%氯化钠注射液100 ml配制。注射用七叶皂苷钠的不良反应主要表现为静脉炎(9例);2例严重的不良反应表现为急性肾损伤,均存在联合用药情况。结论:我院注射用七叶皂苷钠的应用基本合理。临床应按照药品说明书使用该药,警惕联合用药导致的急性肾损伤,尤其注意与含有银杏内脂成分的药物联合应用。临床药师应通过CHPS系统主动监测功能,发现特定药物的不良反应规律,促进临床合理用药。OBJECTIVE: To investigate the clinical application of sodium aescinate for injection, so as to provide references for rational drug use. METHODS: Active monitoring of Chinese hospital pharmacovigilance system(CHPS) was adopted. The medical records of 486 patients with sodium aescinate for injection in the Affiliated Yancheng Hospital of Southeast University Medical College(hereinafter referred to as "our hospital") from Sept. 2017 to Sept. 2018 were retrieved. Statistical analysis was performed on the use of sodium aescinate for injection to evaluate the rationality of drug use. RESULTS: Of the 486 patients who received sodium aescinate for injection, 292 were males and 194 were females;the mean age was 53.62 years;the primary diseases were fracture, trauma and varicose veins;the reason of drug use was to reduce postoperative tissue edema or venous reflux disorder;the dosage of 378 patients was 10 mg, 104 patients was 5 mg, and 4 patients was 20 mg;the route of administration was intravenous drip or intravenous injection, and the solvent was mainly 0.9% sodium chloride injection or 10% glucose injection. Improper application of sodium aescinate for injection was mainly manifested by inappropriate solvent volume,a total of 15 patients were prepared with glucose injection or 100 ml of 0.9% sodium chloride injection. The main adverse drug reactions of sodium aescinate for injection were phlebitis(9 cases);severe adverse drug reactions presented as acute kidney injury in 2 cases, all of which were the drug combination. CONCLUSIONS: The application of sodium aescinate for injection in our hospital is basically reasonable. Clinically, the drug should be used in accordance with the instructions for the drug, and the acute kidney injury caused by the combined use of the drug should be alerted, especially in combination with the drug containing ginkgo lactone. Clinical pharmacists should actively monitor the function of CHPS system to find the adverse drug reactions of specific drugs and promote rational clinical use.

关 键 词：注射用七叶皂苷钠 药品不良反应 合理用药 

分 类 号：R972[医药卫生—药品]