男性不育患者HPV感染与精液指标的相关性研究  

Study on the correlation between HPV infection and semen clinical indexes in infertile men

作　　者：骆峻 石亮[3] 史恒川[2] 丁利军[3] 张星 王国平 LUO Jun;SHI Liang;SHI Hengchuan;DING Lijun;ZHANG Xing;WANG Guoping(Central Laboratory,Jiangsu Health Vocational College,Nanjing,Jiangsu 210029, China;Department of Clinical Laboratory,Jiangsu Province Official Hospital,Nanjing,Jiangsu 210002,China;Department of Andrology,Drum Tower Hospital Affiliated to Medical College of Nanjing University,Nanjing,Jiangsu 210001,China;Department of Urological Surgery,Yangzhou Hospital of Traditional Chinese Medicine,Yangzhou,Jiangsu 225009,China;Department of Clinical Laboratory,Yangzhou Hospital of Traditional Chinese Medicine,Yangzhou,Jiangsu 225009,China)

机构地区：[1]江苏卫生健康职业学院中心实验室,江苏南京210029 [2]江苏省省级机关医院检验科,江苏南京210002 [3]南京大学医学院附属鼓楼医院男科,江苏南京210001 [4]扬州市中医院泌尿外科,江苏扬州225009 [5]扬州市中医院检验科,江苏扬州225009

出　　处：《国际检验医学杂志》2019年第19期2327-2330,2335,共5页International Journal of Laboratory Medicine

基　　金：国家自然科学基金项目(81571391);南京市浦口区科技发展计划(S2017-10)

摘　　要：目的观察男性不育患者人乳头瘤病毒(HPV)感染与精液临床常用指标间的相关性。方法收集436例不孕不育门诊男性精液样本,用PCR-荧光探针法进行HPV 26分型检测,分为HPV阴性组、高危型HPV阳性组和低危型HPV阳性组,对3组精液样本HPV检测结果及临床指标相关性进行统计学分析。结果 436例中28例患者样本HPV阳性(6.14%),共检出HPV型别30个,其中高危型17个、低危型13个;高危型HPV阳性组前向运动率(PR)指标低于低危型HPV阳性组和HPV阴性组,差异有统计学意义(P=0.03);高危型HPV阳性组中段缺陷率指标高于低危型HPV阳性组和HPV阴性组,差异有统计学意义(P=0.04)。结论男性HPV感染可能影响精子活力、增加畸形率,从而降低精液质量,影响男性生育能力,是男性不育的危险因素之一。Objective To observe the correlation between HPV infection in male semen and common clinical indicators of semen.Methods 436 semen samples of infertile men were collected and detected for HPV 26 typing by PCR-fluorescence probe.The semen samples were divided into three groups:HPV(-)group,hrHPV group and lr-HPV group.The semen clinical indicators of the three groups were statistically analyzed.Results Among 436 cases,28 cases were HPV positive(6.14%),and 30 HPV types were detected,including17 high-risk types and 13 low-risk types.The forward movement rate(PR)index of hr-HPV group is lower than lr-HPV group and HPV(-)group,with significant difference among the three groups(P=0.03).The midcourse defect index(MDI)of hr-HPV group is higher than lr-HPV group and HPV(-)group,with significant difference among the three groups(P=0.04).Conclusion Male HPV infection may affect sperm motility,increase the rate of deformity,thus affecting male fertility.

关 键 词：男性不育 人乳头瘤病毒 精液 

分 类 号：R698.2[医药卫生—泌尿科学]