红霉素序贯疗法对肺炎支原体肺炎患儿的疗效及体内血清细胞因子的影响  

Effect of erythromycin sequential therapy on Mycoplasma pneumoniae pneumonia in children and changes of serum cytokines in vivo

作　　者：王慧燕 李红梅[1] WANG Huiyan;LI Hongmei(Department of Pediatrics,First People′s Hospital of Lianyungang City,Lianyungang,Jiangsu 222000,China)

机构地区：[1]连云港市第一人民医院儿科

出　　处：《国际检验医学杂志》2019年第19期2365-2368,共4页International Journal of Laboratory Medicine

摘　　要：目的分析红霉素序贯疗法对肺炎支原体肺炎患儿的疗效及体内血清细胞因子变化的影响。方法选取该院2016年6月至2018年12月收治的肺炎支原体肺炎患儿84例,随机分为对照组和观察组。两组患儿入院后均给予常规治疗,对照组在常规治疗基础上采用红霉素常规静脉滴注治疗,观察组在常规治疗基础上采用红霉素序贯疗法治疗,分析两组患儿的临床疗效。结果观察组总有效率为90.48%,对照组为71.43%,观察组患儿总有效率高于对照组,差异有统计学意义(P<0.05)。两组治疗前血清干扰素-γ(IFN-γ)、白细胞介素-4(IL-4)及IFN-γ/IL-4水平比较,差异无统计学意义(P>0.05)。观察组治疗后IFN-γ、IFN-γ/IL-4水平低于对照组,差异有统计学意义(P<0.05);观察组治疗后IL-4水平与对照组比较,差异无统计学意义(P>0.05)。两组治疗前白细胞介素-10(IL-10)、血清Clara细胞分泌蛋白(CCSP)、可溶性白细胞介素2受体(sIL-2R)水平比较,差异无统计学意义(P>0.05)。观察组治疗后CCSP水平高于对照组,IL-10、sIL-2R水平低于对照组,差异有统计学意义(P<0.05)。观察组不良反应率为2.38%,对照组为14.29%,观察组患儿不良反应率低于对照组,差异有统计学意义(P<0.05)。结论红霉素序贯疗法治疗肺炎支原体肺炎疗效显著,可改善IFN-γ、IFN-γ/IL-4、CCSP、sIL-2R的表达水平,且并不增加不良反应,安全性高。Objective To analyze the effect of erythromycin sequential therapy on children with Mycoplasma pneumoniae pneumonia and the changes of serum cytokines in children.Methods Eighty-four children with Mycoplasma pneumoniae pneumonia admitted to a hospital from June 2016 to December 2018 were randomly divided into control group and observation group.The two groups of children were given conventional treatment after admission,the control group was treated with routine intravenous infusion of erythromycin on the basis of conventional treatment,the observation group was treated with sequential therapy of erythromycin on the basis of conventional treatment,and the clinical efficacy of the two groups of children after treatment was analyzed.Results The total effective rate of the observation group was 90.48%,and that of the control group was 71.43%.The total effective rate of the observation group was higher than that of the control group(P<0.05).Before treatment,serum levels of interferon-γ(IFN-γ),interleukin-4(IL-4)and IFN-γ/IL-4 were compared between the two groups,and the differences were not statistically significant(P>0.05).After treatment,IFN-γand IFN-γ/IL-4 levels in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).There was no significant difference in IL-4 level between the observation group and the control group after treatment(P>0.05).Before treatment,interleukin-10(IL-10),clara cell secretory protein(CCSP)and soluble interleukin-2 receptor(sIL-2 R)levels between the two groups were not statistically significant(P>0.05).After treatment,CCSP levels in the observation group were higher than those in the control group,and IL-10 and sIL-2 Rlevels were lower than those in the control group,the difference was statistically significant(P<0.05).The adverse reaction rate in the observation group was 2.38%,and that in the control group was 14.29%.The adverse reaction rate in the observation group was lower than that in the control group,the differenc

关 键 词：红霉素 序贯疗法 支原体肺炎 干扰素-Γ 白细胞介素-4 

分 类 号：R725.6[医药卫生—儿科]