长链酰胺衍生物对鲍曼不动杆菌生物膜抑制剂的抑制活性测试  

Biofilm Inhibitory Activity of Long Chain Amide Derivatives on AcinetobacterBaumannii

作　　者：杨元勇 程铖 李应贤 周顺[2] 郑丹丹 YANG Yuan-yong;CHENG Cheng;LI Ying-xian;ZHOU Shun;ZHENG Dan-dan(School of Pharmacy,Guizhou Medical University,Guiyang 550025,China;Anshun Environmental Monitoring Station,Anshun 561000,China)

机构地区：[1]贵州医科大学药学院,贵州贵阳550025 [2]贵州省安顺市环境监测站,贵州安顺561000

出　　处：《化工管理》2019年第28期119-121,共3页Chemical Engineering Management

基　　金：国家自然科学基金81660348;贵阳市卫计委基金gzwjkj2018-1-059

摘　　要：细菌的生物膜是细菌耐药性产生的重要原因。文章通过对信号分子进行结构改造,将高丝氨酸内酯环进行替换和改变以合成一系列高丝氨酸内酯结构类似物,并对其进行生物膜抑制活性测试。课题组成功合成了9个化合物,经高分辨质谱、氢谱和碳谱解析其结构。9个化合物对鲍曼不动杆菌生物膜均有抑制作用,生物膜降低了26%~57%。Bacterial biofilm is an important cause of bacterial resistance. The aim of this paper is to synthesis a series of homoserine lactone analogues and tests their biofilm inhibitory activity in order to obtain high performance biofilm inhibitors. Nine compounds were successfully synthesized and their structures were identified by HRMS, 1 HNMR and 13 CNMR. Nine compounds have inhibitory effects on Acinetobacter baumannii biofilm, the amount of biofilm decreased from 26%~57%.

关 键 词：鲍曼不动杆菌 生物膜抑制剂 合成与测试 

分 类 号：R96[医药卫生—药理学]