依达拉奉联合尼莫地平治疗高血压脑出血的疗效研究  

Efficacy of Edaravone Combined with Nimodipine in the Treatment of Hypertensive Intracerebral Hemorrhage

作　　者：李兴强[1] 常静[2] LI Xing-qiang;CHANG Jing(Department of Critical Care Medicine,Shandong Coal Taishan Sanatorium,Tai'an,Shandong Province,271000 China;Department of Oncology,Shandong Academy of Medical Sciences,Jinan,Shandong Province,250031 China)

机构地区：[1]山东省煤炭泰山疗养院重症医学科,山东泰安271000 [2]山东省医学科学院附属医院肿瘤内科,山东济南250031

出　　处：《中外医疗》2019年第25期121-123,共3页China & Foreign Medical Treatment

摘　　要：目的对依达拉奉与尼莫地平联合应用对高血压脑出血患者进行治疗的价值进行探究。方法便利选择该院收治的确诊为高血压脑出血的患者共计120例(2017年6月-2018年8月期间)作为研究对象,按照单双数法将该次研究纳入的所有患者随机划分为对照组和观察组,每组60例。采用常规治疗方式治疗对照组患者,在此基础上,采用依达拉奉联合尼莫地平治疗观察组患者,对两组患者的治疗效果进行分析和比较。结果对照组与观察组治疗前的NIHSS评分分别为(28.11±6.37)分、(28.09±6.31)分,两组患者治疗前的NIHSS评分相比,差异无统计学意义(t=0.475,P>0.05)。对照组与观察组治疗后的NIHSS评分为(22.51±4.92)分、(16.38±3.71)分,两组患者进行比较,差异有统计学意义(t=4.082,P<0.05)。在经过精心的治疗后,对照组患者共计达到了66.7%的总有效率,观察组患者共计达到了91.7%的总有效率,两组患者进行比较,差异有统计学意义(P<0.05)。在治疗期间,对照组中出现1例上消化道出血,不良反应发生率为1.7%,观察组无任何不良反应。在不良反应发生率方面,两组患者进行比较,差异无统计学意义(χ~2=0.158,P>0.05)。结论在高血压脑出血患者的临床治疗中应用依达拉奉联合尼莫地平具有十分显著的效果,能够使患者的神经功能得到有效改善,并且具有很高的安全性。Objective To investigate the value of edaravone combined with nimodipine in the treatment of patients with hypertensive intracerebral hemorrhage. Methods A total of 120 patients (from June 2017 to August 2018) who were diagnosed with hypertensive intracerebral hemorrhage admitted to this hospital were conveniently selected as subjects. All patients included in this study were randomly divided into control group and observation group according to the single and double method, each group has 60 cases. The patients in the control group were treated with conventional treatment. On the basis of this, the patients in the observation group were treated with edaravone combined with nimodipine, and the therapeutic effects of the two groups were analyzed and compared. Results The NIHSS scores of the control group and the observation group were (28.11±6.37)points,(28.09±6.31)points, respectively. There was no statistically significant difference in the NIHSS scores between the two groups before treatment(t=0.475,P>0.05). The NIHSS scores of the control group and the observation group were (22.51±4.92)points,(16.38±3.71)points. There were statistically significant differences between the two groups(t=4.082,P<0.05). After careful treatment, the total number of patients in the control group reached a total effective rate of 66.7%. The total effective rate of the observation group reached 91.7%. There was a statistically significant difference between the two groups (P<0.05). During the treatment period, 1 case of upper gastrointestinal hemorrhage occurred in the control group, and the incidence of adverse reactions was 1.7%. There was no adverse reaction in the observation group. In terms of the incidence of adverse reactions, the difference between the two groups was not statistically significant(χ2=0.158, P>0.05). Conclusion The application of edaravone combined with nimodipine in the clinical treatment of patients with hypertensive cerebral hemorrhage has a very significant effect, which can effectively improve the neu

关 键 词：依达拉奉 尼莫地平 高血压脑出血 神经功能 不良反应 

分 类 号：R4[医药卫生—临床医学]