舒肝宁注射液与0.9%氯化钠注射液配伍稳定性研究  

Study of Compatible Stability on ShuGanNing Injection with 0.9% Sodium Chloride Injection

作　　者：林小明[1] 黄敏[2] 谢培德 LIN Xiao-ming;HUANG Min;XIE Pei-de(People′s Hospital of Guigang City,Guigang 537100,China;The First Affiliated Hospital of Guangxi Traditional Chinese Medicine University,Nanning 530023,China;Guangxi Institute for Food an d Drug Control,Nanning 530021,China)

机构地区：[1]贵港市人民医院,广西贵港537100 [2]广西中医药大学第一附属医院,广西南宁530023 [3]广西食品药品检验所,广西南宁530021

出　　处：《海峡药学》2019年第9期104-107,共4页Strait Pharmaceutical Journal

摘　　要：目的 考察舒肝宁注射液与0.9%氯化钠注射液配伍的稳定性。方法 将舒肝宁注射液按临床使用的质量浓度与0.9%氯化钠注射液配伍。根据《中国药典》的方法分别检测配伍液放置0、2、4、6h后的外观、pH值、不溶性微粒的变化,同时采用HPLC测定配伍液中绿原酸、栀子苷、黄芩苷、黄芩素、野黄芩苷的含量。结果 配伍液的外观、pH值、各有效成分含量于6h内均无明显的变化,不溶性微粒数量0~6h内也符合标准。结论 舒肝宁注射液与0.9%氯化钠注射液配伍在6h内稳定。OBJECTIVE To study the stability of ShuGanNing injection combined with 0.9%sodium chloride injection. METHODS ShuGanNing injection were mixed with 0.9% sodium chloride injection according to mass concentration in the clinic respectively.According to Chinese Pharmacopeia,the fluid compatibility testing of the appearance,value of pH,insoluble particles were performed at 0,2,4,6h after the preparation.Chlorogenic acid,geniposide,scutellarin,baicalin,baicalein were determined by HPLC. RESULTS There were no changes in appearance,value of pH,the content of Chlorogenic acid ,geniposide,scutellarin,baicalin,baicalein of mixture within 6h.The number of insoluble particles was in line with the standard of mixture within 6h.CONCLUSION The compatibility of ShuGanNing Injection with 0.9% sodium chloride injection is stable within 6h.

关 键 词：舒肝宁注射液 0.9%氯化钠注射液 配伍 稳定性 

分 类 号：R927[医药卫生—药学]