HIV/HBV合并感染者的HBeAg状态与免疫重建的关系  

The Relationship Between HBeAg Status and Immune Reconstruction in the Patients of HIV/HBV Co-infections

作　　者：陈念 柯柳[2] 苏明华[3] 温小凤[2] CHEN Nian;KE Liu;SU Minghua;WEN Xiaofeng(Department of Infection,the First Peopler s Hospital of Nanning,Nanning 530022,China;Department of Infection,the People's Hospital of Liuzhou 545006,China;The First Affiliated Hospital of Guangxi Medical University,Nanning 530021 ,China)

机构地区：[1]南宁市第一人民医院感染性疾病科,广西南宁530022 [2]柳州市人民医院感染病科,广西柳州545006 [3]广西医科大学第一附属医院感染性疾病科,广西南宁530021

出　　处：《中国皮肤性病学杂志》2019年第10期1158-1160,共3页The Chinese Journal of Dermatovenereology

基　　金：广西教育厅基金资助项目(YB2014064);广西卫生厅基金资助项目(Z2011346);广西南宁市青秀区科技局基金资助项目(2013ZH02);广西广西卫生厅自筹课题(z2014410);柳州市应用技术研究与开发计划课题(2015J030519)

摘　　要：目的了解人类免疫缺陷病毒(HIV)/乙型肝炎病毒(HBV)合并感染者的HBeAg状态与高效抗反转录病毒治疗(HAART)后患者免疫重建的关系。方法69例HIV/HBV合并感染者按HBeAg的状态分为HBeAg阳性组(26例)和HBeAg阴性组(43例);分别对两组患者治疗后1年、2年、3年的CD4^+T淋巴细胞的增长值进行比较。结果两组患者在接受HAART治疗3年后,外周血HIV RNA载量均低于检测下限(<20拷贝/mL)。两组患者基线CD4^+T淋巴细胞计数的比较差异无统计学意义。HBeAg阴性组合并感染者接受HAART治疗后1年、2年、3年的CD4^+T细胞计数的增长值均明显低于HBeAg阳性组合并感染者,差异具有统计学意义(P<0.05)。结论HBeAg的状态可能影响HIV/HBV合并感染者接受HAART治疗后的免疫重建。Objective To investigate the relationship between the HBeAg status of HIV/ hepatitis B virus ( HBV) co-infected patients and immune reconstruction after highly active antiretroviral therapy ( HAART). Methods According to the status of HBeAg ,69 HIV/HBV co-infected patients were divided into the HBeAg positive (26 cases) and the HBeAg negative group (43 cases). The proliferation of CD4^+ T lymphocytes was compared between the two groups 1 to 3 years after HAART treatments. Results The proliferation of CD4^+ T lymphocytes in the HBeAg negative group were significantly lower than that in the HBeAg positive group in the first, second and third year after HAART treatment (P <0. 05 ). Conclusion The status of HBeAg may affect the immune reconstruction after HAART in patients with HIV/ HBV co-infections.

关 键 词：人类免疫缺陷病毒 乙型病毒性肝炎 高效抗逆转录治疗 

分 类 号：R593.3[医药卫生—内科学] R512.62[医药卫生—临床医学]