遗传因素与胸科手术后慢性疼痛综合征发生的关系:IL-8和NF-κB1的基因多态性  

Relationship between genetic factors and occurrence of chronic post-thoracotomy pain syndrome:interleukin-8 and NF-kappa B1 genetic polymorphisms

作　　者：袁飞 周金萍[2] 张爱春 孙丽丽[1] 温小红[1] 冯智英[1] Yuan Fei;Zhou Jinping;Zhang Aichun;Sun Lili;Wen Xiaohong;Feng Zhiying(Department of Pain Medicine,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,310003 China;Department of Anesthesiology,Shaoxing Second Hospital,Shaoxing 312000,China;Department of Pain Medicine,Sanmen Hospital,Taizhou 317100,China)

机构地区：[1]浙江大学医学院附属第一医院麻醉疼痛科,杭州310003 [2]绍兴第二医院麻醉科,312000 [3]三门县人民医院疼痛科,台州市317100

出　　处：《中华麻醉学杂志》2019年第6期703-706,共4页Chinese Journal of Anesthesiology

基　　金：浙江省医药卫生科技项目(2016C37104).

摘　　要：目的从基因多态性角度,探讨遗传因素对胸科手术后慢性疼痛综合征(PTPS)发生的影响.方法择期行胸腔镜下肺癌根治术病人200例,性别不限,ASA分级Ⅰ或Ⅱ级,年龄18~80岁.术前采血提取DNA后进行rs4073、rs3774932等20个单核苷酸多态性(SNP)位点的分析.采用多模式术后镇痛,维持病人VAS评分<3分.术后2~4个月随访PTPS的发生情况.根据是否发生PTPS分为2组:非PTPS组(N组)和PTPS组(P组).结果术后PTPS发生率38.7%,N组114例,P组72例.2组病人IL-8 rs4073位点及NF-κB1 rs3774932位点的A/T等位基因频率和基因型频率比较差异有统计学意义(P<0.05).结论 IL-8和NF-κB1的基因多态性与病人PTPS的发生有关.Objective To investigate the effect of genetic factors on the occurrence of chronic post-thoracotomy pain syndrome ( PTPS) from the perspective of genetic polymorphisms. Methods Two hun-dred patients of both sexes, of American Society of Anesthesiologists physical statusⅠ or Ⅱ, aged 18-80 yr, scheduled for elective video-assisted thoracoscopic radical lung cancer surgery, were enrolled in this study. Blood samples were taken before operation for genotype analysis of 20 SNP loci, such as rs4073 and rs3774932, after DNA extraction. Postoperative multimodal analgesia was applied to maintain the visual an-alogue scale score <3. All the patients were followed up for 2-4 months after operation to record the occur-rence of PTPS. The patients were divided into 2 groups according to whether PTPS occurred: non-PTPS group (group N) and PTPS group (group P). Results The incidence of PTPS was 38. 7% after surgery, and there were 114 patients in group N and 72 cases in group P . There was significant difference in A/T al-lele and genotype frequency at interleukin-8 rs4073 site and NF-κB1 rs3774932 site between the two groups (P<0. 05). Conclusion Interleukin-8 and NF-kappa B1 genetic polymorphisms are associated with the occurrence of PTPS.

关 键 词：疼痛 手术后 多态性 单核苷酸 白细胞介素8 NF-κB1 

分 类 号：R614[医药卫生—麻醉学]