糖皮质激素受体在慢性鼻-鼻窦炎伴鼻息肉激素敏感性中的研究进展  

Advances in the study of glucocorticoid receptors in glucocorticoid sensitivity of chronic rhinosinusitis with nasal polyps

作　　者：邵姗[1] 鲍诗平[1] 王向东[2] 张罗[2] Shao Shan;Bao Shiping;Wang Xiangdong;Zhang Luo(Department of Otolaryngology Head and Neck Surgery,Beijing You'an Hospital,Capital Medical University,Beijing 100069,China;Department of Otolaryngology Head and Neck Surgery,Beijing TongRen Hospital,Capital Medical University,Beijing Institute of Otolaryngology,Key Laboratory of Otolaryngology Head and Neck Surgery(Capital Medical University),Ministry of Education,Beijing Key L aboratoty of Nasal Disease,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京佑安医院耳鼻咽喉头颈外科,北京100069 [2]首都医科大学附属北京同仁医院耳鼻咽喉头颈外科,北京市耳鼻咽喉科研究所,耳鼻咽喉头颈科学教育部重点实验室(首都医科大学),鼻病研究北京重点实验室,北京100730

出　　处：《国际耳鼻咽喉头颈外科杂志》2019年第5期300-304,共5页International Journal of Otolaryngology-Head and Neck Surgery

基　　金：国家自然科学基金重点国际合作项目(81420108009);国家自然科学基金重点项目(81630023);国家自然科学基金面上项目(81570894);教育部长江学者和创新团队(IRT13082);北京市自然科学基金面上项目(7172054);北京市科技新星计划交叉学科合作课题(xxjc201712);北京市医院管理局使命人才计划(SML20150203);北京市科技项目统筹课题(Z171100000117002)联合资助.

摘　　要：慢性鼻-鼻窦炎是一种临床常见,具有高度异质性,发病机制复杂的鼻黏膜持续反应性炎性疾病。作为临床中治疗鼻-鼻窦炎的一线药物,糖皮质激素的生物学效应主要由糖皮质激素受体介导。该受体的表达具有明显的异质性,受转录水平、翻译水平以及翻译后修饰等多层面调控。慢性鼻-鼻窦炎疾病本身和激素治疗以及所处微环境变化会影响糖皮质激素受体的表达及功能,最终影响糖皮质激素的敏感性。本文总结了糖皮质激素受体在慢性鼻-鼻窦炎伴鼻息肉激素敏感性中的研究进展。Chronic rhinosinusitis is a clinically common, highly heterogeneous, complexly pathological group of diseases involving the paranasal sinuses with a shared feature of persistent inflammation. As a first-line drug for the treatment of chronic rhinosinusitis, the biological effects of glucocorticoids are mainly mediated by glucocorticoid receptors. The isoform expression of glucocorticoid receptors has been shown obvious heterogeneity, which is mainly regulated by various levels, such as transcription level, translational level and post-translational modifications. Different disease states of chronic rhinosinusitis with nasal polypsand glucocorticoid treatments as well as changes in the microenvironment may affect the pool and function of glucocorticoid receptors, which in turn affects the sensitivity of glucocorticoid action. This paper summarized advances in the study of glucocorticoid receptors in glucocorticoid sensitivity of chronic rhinosinusitis with nasal polyps.

关 键 词：鼻窦炎 鼻息肉 糖皮质激素类 受体 糖皮质激素 

分 类 号：R765[医药卫生—耳鼻咽喉科]