血清25-羟维生素D3与慢性HBV感染者的相关性研究  

Correlation between Serum 25-hydroxyvitamin D3 and Chronic HBV Infection

作　　者：张立华[1] 丁艾昆[2] 巩灿灿 张卫华[4] 王昌源[5,6] ZHANG Li-hua;DING Ai-kun;GONG Can-can;ZHANG Wei-hua;WANG Chang-yuan(Intensive Care Unit,Jinan Infectious Disease Hospital, Jinan, Shandong Province, 250021 China;Seven Section, Jinan Infectious Disease Hospital, Jinan, Shandong Province, 250021 China;Department of Infectious Diseases, Yantaishan Hospital, Yantai, Shandong Province, 264000 China;Department of Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan, Shandong Province, 250031 China;Infectious diseases teaching and research section, school of medicine, shandong university, Jinan, Shandong Province, 250021 China;Four Section,Jinan Infectious Disease Hospital, Jinan, Shandong Province, 250021 China)

机构地区：[1]济南市传染病医院重症监护室,山东济南250021 [2]济南市传染病医院七科,山东济南250021 [3]烟台市烟台山医院感染科,山东烟台264000 [4]山东省医学科学院附属医院内五科,山东济南250031 [5]山东大学医学院传染病学教研室,山东济南250021 [6]济南市传染病医院四科,山东济南250021

出　　处：《系统医学》2019年第16期45-47,共3页Systems Medicine

基　　金：济南市卫生局(2014WS0201)

摘　　要：目的探讨血清25-羟维生素D3与慢性HBV感染者的相关性。方法收集济南市传染病医院2015年1月—2019年1月门诊及住院的慢性HBV感染患者620例,根据疾病的严重程度分为4组,即无症状ASC组(ASC)120例,慢性乙型肝炎组(CHB)160例,乙型肝炎肝硬化组(LC)200例,肝细胞性肝癌组(HCC)138例;同时,选取同期健康查体者140名作为健康对照(Healthcontrol,HC)。回顾性收集患者的乙肝病毒学和血清学标志物、肝功及生化指标、影像学资料等,并检测所用纳入者的血清25-羟维生素D3(25(OH)D3)的含量。结果性别与年龄组成:HC组共140例,平均年龄(31.96±8.91)岁;慢性HBV感染者620例,平均年龄(43.14±13.60)岁,慢性HBV感染者平均年龄高于HC组,差异有统计学意义(t=-7.75,P<0.001)。各组血清25(OH)D3含量:HC组平均含量(32.99±7.33)ng/mL,患病组平均含量(29.28±7.33)ng/mL,两组差异有统计学意义(t=4.64,P<0.001)。,健康组与慢性HBV患者25(OH)D3缺乏状态的比较,25(OH)D3含量(ng/mL)正常(≥30 ng/mL)、不足(20-29.9)、缺乏(≤19.9 ng/mL),HC组分别为105、30、5例;慢性HBV感染者分别为320、220、80例;(χ~2=18.42,P<0.001)。各组HBVDNA载量,高HBVDNA载量随着病情的进展呈逐渐降低的趋势,以HCC组所占比例最低;各组间差异有统计数意义(P<0.001)。结论血清25-羟维生素D3与慢性HBV感染者具有明显的相关性,可以作为肝炎的参考指标。Objective To investigate the relationship between serum 25-hydroxyvitamin D3 and chronic HBV infection. Methods A total of 620 patients with chronic HBV infection who were outpatients and hospitalized in Jinan Infectious Disease Hospital from January 2015 to January 2019 were enrolled. According to the severity of the disease, they were divided into 4 groups, namely 120 cases of asymptomatic ASC group (ASC). Chronic B 160 cases of hepatitis group (CHB), 200 cases of hepatitis B cirrhosis group (LC) and 138 cases of hepatocellular carcinoma group (HCC). At the same time, 140 cases of healthy physical examination were selected as health control (HC). Hepatitis B virology and serological markers, liver function and biochemical indicators, imaging data, etc. were collected retrospectively, and the serum 25 -hydroxyvitamin D3 (25(OH)D3) content of the incorporation was measured. Results Gender and age composition: 140 patients in the HC group, mean age (31.96±8.91) years old;620 patients with chronic HBV infection, mean age (43.14±13.60) years old(χ2 =0.79, P=0.357), average of chronic HBV infection age was higher than the HC group, and the difference was statistically significant (t=-7.75, P<0.001). Serum 25 (OH)D3 content in each group: the average content of HC group (32.99±7.33)ng/mL, the average content of diseased group (29.28±7.33)ng/mL, there was significant statistical difference between the two groups (t=4.64, P<0.001), 25 (OH) D3 content (ng/mL) normal (≥30 ug/mL), insufficient (20~29.9 ng/mL), lack (≤19.9 ng/mL) in the healthy group and chronic HBV patients, HC group 105 cases, 30 cases, 5 cases;chronic HBV infection were 320 cases, 220 cases, 80 cases (χ^2 =18.42, P<0.001). The HBV DNA load and high HBV DNA load of each group gradually decreased with the progress of the disease, and the proportion of HCC group was the lowest. There was significant statistical significance between the groups (P<0.001). Conclusion Serum 25-hydroxyvitamin D3 has a significant correlation with chronic HBV infection

关 键 词：血清25-羟维生素D3 慢性HBV 感染者 相关性 

分 类 号：R4[医药卫生—临床医学]