医用交联透明质酸钠凝胶微球的制备及性能  

Preparation and Character of Clinical Cross-linked Sodium Hyaluronate Gel Microspheres

作　　者：周奎 邓连霞 杜瑶瑶 黄伟 ZHOU Kui;DENG Lian-xia;DU Yao-yao;HUANG Wei(Hangzhou Singclean Medical Products Co.,Ltd.,Hangzhou,Zhejiang 310018,China)

机构地区：[1]杭州协合医疗用品有限公司

出　　处：《浙江化工》2019年第9期6-10,共5页Zhejiang Chemical Industry

基　　金：国家国际科技合作专项项目(2015DFA51010)

摘　　要：研究采用乳化法制备医用交联透明质酸钠凝胶微球,通过对乳化转速、乳化时间、油水比、透明质酸钠起始浓度、乳化剂浓度的研究,来考察各因素对医用交联透明质酸钠凝胶微球粒径的影响,结果表明:当透明质酸钠起始浓度为8%、油水比为1/4、乳化剂浓度为1.5%、乳化转速为2500 r/min、乳化时间为20 min时,所研制的医用交联透明质酸钠凝胶微球平均粒径为30.8μm,并进一步对所制备的透明质酸钠凝胶微球进行性能检测,各项指标均达到预期要求。The microspheres of clinical cross-linked sodium hyaluronate gel were prepared by emulsion method in water-in-oil(w/o) emulsions. The factors of preparation including stirring speed, emulsification time, oil/water ratio, initial concentration of HA and concentration of emulsifier were studied. The results showed that when the initial concentration of HA was 8%, the ratio of oil to water was 1:4, the emulsifier concentration was 1.5%, the emulsification speed was 2500 r/min, the emulsification time was 15 min,the average particle size of clinical cross-linked sodium hyaluronate gel microspheres was 30.8 μm. The performance of the prepared sodium hyaluronate gel microspheres was measured. The results were expected to meet the requirements.

关 键 词：乳化法 交联 透明质酸钠凝胶 微球 粒径 

分 类 号：TQ460.6[化学工程—制药化工] TQ427.26