盐酸安非他酮缓释片联合行为干预真实世界戒烟效果研究  

A study on the real world effect of the combination of bupropion hydrochloride sustained release tablets with behavior intervention on smoking cessation

作　　者：李荣[1] 解世林 张励[1] 王晓楠[1] 康健[1] 胡雪君[1] LI Rong;XIE Shi-lin;ZHANG Li;WANG Xiao-nan;KANG Jian;HU Xuejun(Department of Geriatrics,Respiratory Research Institute,the First Affiliated Hospital of China Medical University,Shenyang 110001,China)

机构地区：[1]中国医科大学附属第一医院呼吸研究所老年医学科

出　　处：《中国实用内科杂志》2019年第10期873-878,共6页Chinese Journal of Practical Internal Medicine

基　　金：国家重点研发计划重大慢性非传染性疾病防控重点专项(2017YFC1309403)

摘　　要：目的探讨盐酸安非他酮缓释片联合心理干预及微信平台宣传、随访的真实世界戒烟疗效。方法 2018-4-1-2018-11-1在中国医科大学附属第一医院将283例受试者根据个人意愿分为2组,84例选择微信联合心理干预,定义为对照组,199例选择盐酸安非他酮缓释片联合微信宣传、随访及心理干预,定义为治疗组。使用SPSS23.0统计软件比较随访3个月两组持续1月的戒烟率,体重变化及分析影响戒烟率的因素。结果治疗组成功率为57.8%,对照组成功率10.7%,两组差异有统计学意义;群组干预组成功率69.46%,个体干预组53.6%,两组差异有统计学意义;治疗组体重平均增加2.6kg,对照组平均增加3.5kg,差异无统计学意义;是否存在抑郁、干预方式、是否患吸烟相关疾病、吸烟支数、是否为家人要求戒烟、戒烟准备情况5个因素有统计学意义。存在抑郁的戒烟者戒烟失败是无抑郁者的7.772倍;未患吸烟相关疾病戒烟失败是患有吸烟相关疾病者的4.492倍;吸烟支数>20支/d者戒烟失败是≤20支/d者的4.090倍;无家人要求戒烟者戒烟失败是有家人要求者的0.463倍;戒烟准备不充分者戒烟失败是准备充分者的0.274倍;对照组的干预方式戒烟失败是治疗组的14.292倍。结论 (1)盐酸安非他酮缓释片联合心理干预及微信平台可以明显提高戒烟率;(2)朋友或家人同时戒烟可增加戒烟率;(3)影响戒烟成功率的因素包括是否存在抑郁、干预方式、是否患吸烟相关疾病、吸烟支数、是否为家人要求戒烟、戒烟准备情况。Objective To discuss the real world effect of bupropion hydrochloride sustained-release tablets and psychological intervention as well as WeChat publicity and follow-up on smoking cessation. Methods Totally 283 subjects were divided into two groups according to their own wishes: 84 people chose WeChant and psycholigical intervention, and were defined as control group;199 people chose bupropion hydrochloride and WeChant and psycholigical intervention, and were defined as treatment group. The one-month smoking cessation rate and weight changes of the two groups in 3 months was compared, and the factors affecting the smoking cessation rate were analyzed. Results The success rate was 57.8% in treatment group, and the success rate of the control group was 10.7%. There was a statistically significant difference between the two groups. The average weight gain was 2.6 kg in the treatment group, and in the control group it was 3.5 kg, with no statistically significant difference. The presence of depression, intervention pattern, smoking-related disease, the number of cigarettes smoked per day, and the need to quit smoking for family members and the readiness to quit were statistically siginificant factors. The faliure rate of smoking cessation in depressed smokers was 7.772 times that of non-derpessed smokers, and it was4.492 times that of people with smoking related deseases. The failure rate of smoking cessation in people smoking more than20 cigarettes a day was 4.090 times that of pepople smoking less than 20. The failure rate in smokers without family requests of quiting smoking was 0.463 times that of those with requests;the failure rate in smokers without readiness was0.274 times that of those with proper readiness. The failure rate in control group was 14.292 times that of the treatment group. Conclusion Bupropion hydrochloride sustained-release tablets + psychological intervention + WeChat platform promotion can significally increase the rate of sucessful smoking cessation. Factors affecting the success rate of sm

关 键 词：烟草依赖 安非他酮 真实世界 戒烟治疗 

分 类 号：R163[医药卫生—公共卫生与预防医学]