神效散联合四妙散治疗急性痛风性关节炎的临床观察  

Clinical Observation on Treatment of Acute Gouty Arthritis with Shenxiao Powder Combined with Simiao Powder

作　　者：魏万利[1] 李钦宗[1] 郑昆仑[1] 王爱国[1] 王琳珏[1] 谷福顺[1] WEI Wan-li;LI Qin-zong;ZHENG Kun-lun(Department of Orthopaedics,the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300150,China.)

机构地区：[1]天津中医药大学第二附属医院骨科

出　　处：《中国中西医结合外科杂志》2019年第5期720-723,共4页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

基　　金：天津市中医药重点领域科研项目课题(2017007)

摘　　要：目的:观察神效散外用联合四妙散口服治疗急性痛风性关节炎的临床疗效。方法:将急性痛风患者随机分为治疗组与对照组,各42例,对照组患者口服予以口服碳酸氢钠片1g,3次/d,洛索洛芬钠片60mg,2次/d,秋水仙碱片1~3mg/d口服治疗,连续口服14天。治疗组患者在以上治疗基础上,予神效散外用,每天换药1次,同时口服四妙散治疗。两组均连续治疗14天。观察其局部疼痛、关节肿胀、关节活动情况,同时检测血尿酸、白细胞、中性粒细胞、血沉、C反应蛋白等指标。结果:对照组治疗后局部疼痛的症状减轻较明显,与治疗前比较差异有统计学意义(P<0.05);治疗组治疗后疼痛、肿胀及关节活动指标与治疗前比较,统计学有显著性差异(P<0.05);治疗组治疗后疼痛、肿胀指标与对照组治疗后比较,统计学有显著性差异(P<0.05);对照组治疗后与治疗前比较,血尿酸、C反应蛋白、血沉指标差异有统计学意义(P<0.05);治疗组治疗后血尿酸、C反应蛋白等指标与对照组治疗后比较差异有统计学意义(P<0.05)。结论:神效散外用联合四妙散治疗急性痛风性关节炎能够有效改善患处疼痛、肿胀、功能等指标,临床疗效满意,临床可以作为一种治疗手段推广。Objective To observe the clinical efficacy of Shenxiao Powder combined with Simiao Powder in the treatment of acute gouty arthritis.Methods Patients with acute gout were randomly divided into treatment group and control group,42 cases in each group.The patients in control group received oral sodium bicarbonate tablets 1 g/d,3 times daily,and loxoprofen sodium tablets 60 mg,twice daily.Oral treatment of colchicine tablets 1–3mg/d,continuously for 14 d.On the basis of the above treatment,the patients in treatment group were given Shenxiao Powder for external use,once daily for dressing change,and Simiao Powder was given orally.The local pain,joint swelling,joint activity,blood uric acid,white blood cells,neutrophils,erythrocyte sedimentation rate,C-reactive protein and other indicators were observed.Results After treatment,the symptoms of local pain in the control group were significantly alleviated,with significant difference compared with those before treatment(P<0.05).After treatment,the indexes of pain,swelling and joint activity in the treatment group were significantly different from those before treatment(P<0.05).After treatment,the indexes of pain and swelling in the treatment group were significantly different from those in the control group(P<0.05).After treatment,there were significant differences in serum uric acid,C-reactive protein and erythrocyte sedimentation rate between the two groups(P<0.05).After treatment,there were significant differences in serum uric acid and C-reactive protein between the two groups(P<0.05).Conclusion Shenxiao Powder combined with Simiao Powder in the treatment of acute gouty arthritis can effectively improve the pain,swelling,function and other indicators of the affected area.Its clinical effect is satisfactory,and it can be promoted as a treatment in clinic.

关 键 词：急性痛风性关节炎 神效散 四妙散 临床观察 

分 类 号：R589.7[医药卫生—内分泌] R285.6[医药卫生—内科学]