绵羊ADRA1B基因生物信息学分析  

Bioinformatics Analysis of Sheep ADRA1B Gene

作　　者：李娜[1] 王维民[1,2] 张德印 张小雪 LI Na;WANG Weimin;ZHANG Deyin;ZHANG Xiaoxue(College of Animal Science and Technology,Gansu Agricultural University,Lanzhou Gansu 730070,China;Engineering Laboratory of Mutton Sheep Breeding and Reproduction Biotechnology in Gansu Province,Minqin Gansu 733300,China)

机构地区：[1]甘肃农业大学动物科学技术学院,甘肃兰州730070 [2]甘肃省肉羊繁育生物技术工程实验室,甘肃民勤733300

出　　处：《甘肃农业科技》2019年第9期42-48,共7页Gansu Agricultural Science and Technology

基　　金：甘肃农业大学学生科研训练计划项目(201904030);甘肃农业大学盛彤笙科技创新基金(GSAU-STS-1618);甘肃省农业生物技术专项(GNSW-2016-10)

摘　　要：利用生物信息学数据库及软件,对绵羊ADRA1B基因进行生物信息学分析,初步了解其结构并进行预测。结果表明,绵羊ADRA1B基因含有1个1548bp的开放阅读框,编码515个氨基酸残基。ADRA1B蛋白分子质量为56385.55KDa,理论等电点PI为9.53。亚细胞主要定位于质膜,不属于分泌蛋白。不存在信号肽序列。存在七段跨膜结构且有2段低复杂性区域,二级结构以无规卷曲为主,三级结构主要由无规卷曲缠绕折叠形成。参与心肌、血管、肌肉的收缩调节。The bioinformatics analysis of sheep ADRA1B gene was carried out by using bioinformatics database and software,and its structure was preliminarily understood and predicted. The results showed that sheep ADRA1B gene contained an open reading frame of 1 548 bp, encoding 515 amino acid residues. The molecular mass of ADRA1B protein was 56 385.55 KDa, and the theoretical isoelectric point PI was 9.53. The subcells were mainly located in plasma membrane and did not belong to secretory protein. There are no signal peptide sequences;There are seven segments of transmembrane structure and two segments of low complexity regions. The secondary structure is mainly random crimp, and the tertiary structure is mainly formed by random crimp, winding and folding. Involved in the regulation of contraction of myocardium, blood vessels and muscles.

关 键 词：绵羊 ADRA1B基因 生物信息学分析 

分 类 号：S826[农业科学—畜牧学]