Rathke’s裂囊肿手术前后血泌乳素水平的变化分析  

Analysis of prolactin level before and after surgery of Rathke’s cleft cyst

作　　者：廖宇[1] 陈炳宏 胡耀敏[1] 缪亦锋[2] 邱永明[2] LIAO Yu;CHEN Bing-hong;HU Yao-min(Department of Endocrinology and Metabolism,South Campus,Renji Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 201112,China)

机构地区：[1]上海交通大学医学院附属仁济医院南院内分泌科,上海201112 [2]上海交通大学医学院附属仁济医院南院神经外科,上海201112

出　　处：《临床神经外科杂志》2019年第5期439-442,共4页Journal of Clinical Neurosurgery

基　　金：国家自然科学基金面上项目(81870554)

摘　　要：目的探讨垂体Rathkes裂囊肿(Rathkes cleft cyst,RCC)患者手术前后血泌乳素(prolactin,PRL)水平的变化特征。方法回顾性分析上海交通大学医学院附属仁济医院南院2015年6月—2019年6月,行神经内镜下经鼻蝶手术治疗的14例RCC患者的临床资料。采用Wilcoxon秩和检验对比RCC患者术前与术后血PRL水平的差异。结果本组患者中,男6例,女8例;术前血PRL水平升高者7例,术后血PRL水平较术前下降者10例。手术后患者的症状均缓解,血PRL水平比术前明显下降(P=0.0052)。结论RCC可以轻度刺激垂体PRL分泌增加;神经内镜手术治疗RCC可有效降低PRL的分泌水平,对于改善患者的临床症状和血PRL水平有显著效果。Objective To explore the changes of prolactin(PRL) level in Rathke s cleft cyst (RCC) patients before and after surgery. Methods The clinical data of 14 patients with RCC admitted to South Campus, Renji Hospital, School of Medicine, Shanghai Jiaotong University from June 2015 to May 2019 were analyzed retrospectively. All patients underwent neuroendoscopy assisted transsphenoidal surgery and were diagnosed by pathology. Wilcoxon rank sum test was used to compare the difference of PRL level in RCC patients before and after surgery. Results There were 14 eligible patients, including 6 males and 8 females, 7 patients with increased PRL level before surgery, and 10 patients with decreased PRL level after surgery. The PRL level significantly decreased after neuroendoscopy assisted transsphenoidal surgery( P =0.005 2 ). Conclusion Neuroendoscopy assisted transsphenoidal surgery for RCC can effectively reduce PRL level and improve symptoms of patients.

关 键 词：Rathke's裂囊肿 神经内镜 泌乳素 

分 类 号：R651.11[医药卫生—外科学]