检测白细胞介素-6、白细胞介素-8、肿瘤坏死因子-α和超敏C-反应蛋白与前列腺电切术后下尿路症状关系研究  

Study on the relationship between IL-6, IL-8, TNF-α, hs-CRP and LUTS after transurethral resection of prostate hyperplasia

作　　者：刘全启 童建勇 罗荣利 陈良佑 徐旻 朱再生 LIU Quan-qi;TONG Jian-yong;LUO Rong-li;CHEN Liang-you;XU Min;ZHU Zai-sheng(Department of Urology,Jinhua Hospital of Zhejiang University,Jinhua,Zhejiang 321000,China)

机构地区：[1]浙江大学金华医院泌尿外科

出　　处：《中国卫生检验杂志》2019年第18期2234-2236,共3页Chinese Journal of Health Laboratory Technology

基　　金：浙江省医学会临床科研资金项目资助(2012ZYC-A83)

摘　　要：目的检测前列腺电切术后尿液中白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)和超敏C-反应蛋白(hs - CRP)变化,探讨前列腺增生电切术后炎症因子与下尿路症状(LUTS)关系。方法s对135例前列腺增生患者,行经尿道前列腺电切术,全组手术顺利,观察术前1d、术后1周、术后1个月、术后3个月留取患者清晨尿液标本,检测炎症因子IL-6、IL-8、TNF-α及hs-CRP,同时观察患者排尿状况。结果BPH患者电切术后尿液中炎症因子IL-6、IL-8、TNF -α及hs-CRP在术后1 d、术后1周较术前1 d、术后1个月、术后3个月高,差异有统计学意义(P<0.05);术后1 d和术后1周相比未见差异,术前1个月和术后3个月比较差异无统计学意义(P>0.05)。结论BPH 术后尿液中IL-6、IL-8、TNF -α和hs - CRP炎症因子增高,炎症因子下降后LUTS缓解,应用降低炎症药物有利于减轻尿道炎症因子,利于电切术后LUTS恢复。Objective To deteet the changes of IL-6, IL-8, TNF-α and hs-CRP in urine after transurethral resection of prostate hyperplasia, and to explore the relationship between inflammatory factors and LUTS. Methods 135 patients with prostate hyperplasia were treated with transurethral resection, and the operation of the whole group was successful. Urine specimens were collcted on early morning, respectively 1 day before surgery, 1 week aufter surgery, 1 month after surgery, and 3 months after surgery. Inflammatory cytokines α-6,α-8, TNF -α and hs-CRP were detected. Results The ineidence of inflammatory cytokines IL-6,IL-8, TNF-α and hs-CRP in the urine of BPH patients after operation was higher 1 day after surgery aund 1 week after surgery were higher than thal 1 day before surgery, 1 month ufer surgery aund 3 months after surgery, with the differences statistically significant (P<0. 05). There was no difference between 1 day postoperative and 1 week postoperative, and the differences were not statistically significant between 1 month postoperative and 3 months postoperative ( P > 0.05). Conclusion α-6, IL-8,TNF-α and hs-CRP inflammatory factors increased after BPH surgery, and LUTS were relieved after the decrease of inflammatory factors. The application of inflammatory drugs was conducive to the reduction of urethral inflammatory factors and the recovery of LUTS after operation.

关 键 词：前列腺增生 下尿路症状 炎症因子 治疗 

分 类 号：R697.3[医药卫生—泌尿科学]