中性粒细胞及血小板与淋巴细胞的比值在类风湿关节炎中的研究  

Ratios of neutrophils and platelets to lymphocytes in rheumatoid arthritis

作　　者：范欣 俞颖哲 莫翼军[2] 吴爱华 刘艳清 FAN Xin;YU Ying-zhe;MO Yi-jun;WU Ai-hua;LIU Yan-qing(Department of Dermatology, the First Hospital of Ningbo,Ningbo, Zhejiang 315000 , China)

机构地区：[1]宁波市第一医院皮肤科,浙江宁波315000 [2]宁波市第一医院检验科,浙江宁波315000

出　　处：《中国卫生检验杂志》2019年第18期2240-2243,共4页Chinese Journal of Health Laboratory Technology

摘　　要：目的评估中性粒细胞与淋巴细胞比率(NLR)、血小板与淋巴细胞比率(PLR)及其他临床参数与类风湿性关节炎(RA)的关系,并进一步探讨其作为类风湿性关节炎潜在标志物的可能性。方法回顾性分析2016年1月-2018年12月本院207例RA患者。根据疾病活动性评分28(DAS28)将RA患者分为3组,分析其C-反应蛋白(CRP)、红细胞沉降率(ESR)及全血细胞计数。同时选取100例健康受试者作为对照组。结果高DAS28组的RA患者NLR和PLR水平高于低DAS8组(P<0.01)和中DAS28组的RA患者。Spearman相关分析表明,NLR和PLR均与DAS28存在正相关关系(r=0.238,r=0.268,P<0.001)。受试者特征曲线分析,NLR和PLR区分低活动性RA患者与中度以上活动性RA患者最佳临界值分别为3.16和217.21。结论NLR和PLR与RA活动性相关且可以区分RA的疾病活动性。NLR和PLR可用作RA患者潜在的预后标志物。Objective To evaluate the levels of the neutrophil to lymphocyte ratio ( NLR ), the platelet to lymphocyte ratio ( PLR ), as well as other clinical param eters in rheumatoid arthritis ( RA ), and further to explore the potential correlations between these markers and rheumatoid arthritis. Methods Totally 207 patients with rheum atoid arthritis and 100 healthy subjects were retrospectively analyzed. The RA patients were divided into 3 groups according to disease activity score-28 ( DAS28 ). The C-reactive protein ( CRP ), erythrocyte sedimentation rate ( ESR ) and complete blood count were reviewed from the m edical records. Results The results showed that RA patients with DAS28-high had higher levels of NLR and PLR than RA patients with DAS28-low and DAS28-moderate ( P <0.01 ). Spearman correlation analysis indicated that both NLR and PLR revealed positive correlations with DAS28 ( r =0.238 , r = 0.268 , P < 0.001 ). The optimal cut-off levels for NLR and PLR to discrim inate RA patients with DAS28-low and RA patients with DAS28-moderate and DAS28-high respectively were 3. 16 and 217. 21 through receiver-operating characteristic curve ( ROC ) analysis. Conclusion NLR and PLR could discrim inate the lower disease activity and higher disease activity for patients with rheum atoid arthritis. NLR and PLR might be used as a potential prognostic m arker for RA patients.

关 键 词：中性粒细胞与淋巴细胞比率 血小板与淋巴细胞比率 疾病活动性评分28 类风湿性关节炎 

分 类 号：R593.22[医药卫生—内科学]