多糖抗肿瘤作用及相关机制研究  

Advances in anti-tumor effects and related mechanisms of polysaccharides

作　　者：林文翰[1] 陈学军 郎伟军 张鑫[1] 韦祖巧 冮剑[1] 于淼[1] LIN Wen-han;CHEN Xue-jun;LANG Wei-jun;ZHANG Xin;WEI Zu-qiao;GANG Jian;YU Miao(Research Center on Life Sciences and Environmental Sciences,Harbin University of Commerce,Harbin 150076,China;Harbin Yu Zhou Ren Tai Pharmaceutical Engineering Research Center Co.,Ltd.,Harbin 150076,China;Harbin Letai Pharmaceutical Co.,Ltd.,Harbin 150076,China)

机构地区：[1]哈尔滨商业大学生命科学与环境科学研究中心,哈尔滨150076 [2]哈尔滨宇洲仁泰药物工程研究中心有限公司,哈尔滨150076 [3]哈尔滨乐泰药业股份有限公司,哈尔滨150076

出　　处：《哈尔滨商业大学学报（自然科学版）》2019年第5期534-538,共5页Journal of Harbin University of Commerce：Natural Sciences Edition

基　　金：黑龙江省教育厅科学技术研究项目(12541216)

摘　　要：介绍多糖的抗肿瘤作用及相关机制的研究进展,为多糖的临床应用提供理论基础.对近年来国内外关于多糖的相关文献进行分析和总结,较为全面的阐述多糖的抗肿瘤作用及相关机制的研究进展.多糖可分为动物、植物、藻类、菌类多糖等,大多数动物多糖可直接发挥抗肿瘤作用;部分植物多糖可通过阻滞细胞周期发挥抗肿瘤作用;藻类多糖可通过提高免疫功能来发挥抗肿瘤作用;多数菌类多糖可诱导细胞凋亡.多糖可通过直接抑制肿瘤细胞生长、阻滞细胞周期、诱导细胞凋亡、提高机体免疫力等来发挥抗肿瘤作用,且动植物多糖具有毒副作用小、来源广泛、提高机体免疫力等优点,因此,多糖的研究和开发对未来抗肿瘤药物的发展具有重要意义.This paper introduced the research progress of anti-tumor effect and related mechanism of polysaccharide, and provide theoretical basis forclinical application of polysaccharide. To analyze and summarize the related literatures on polysaccharides at home and abroad in recent years, and to comprehensively explain the research progress of anti-tumor effects and related mechanisms of polysaccharides. Polysaccharides can be divided into animals, plants, algae, fungi, etc. Most animal polysaccharides can directly exert anti-tumor effects;some plant polysaccharides can exert anti-tumor effects by blocking the cell cycle;algal polysaccharides can exert anti-tumor effects by improving immune function;most fungal polysaccharides can induce apoptosis. Polysaccharides can exert anti-tumor effects by directly inhibiting tumor cell growth, arresting cell cycle, inducing apoptosis, and improving immunity. Moreover, the polysaccharides of plants and animals have the advantages of small toxic and side effects, wide sources, and improved immunity. Therefore, the research and development of polysaccharides is of great significance for the development of future anti-tumor drugs.

关 键 词：多糖 抗肿瘤 机制研究 进展 

分 类 号：R285[医药卫生—中药学]