成人胰岛细胞增生症的研究进展  

Research progress of adult nesidioblastosis

作　　者：侯琳 周新丽[1] Hou Lin;Zhou Xinli(Department of Endocrinology,Shandong Provincial Hospital Affiliated to Shandong University,Shandong Clinical Medical Center of Endocrinology and Metabolism,Institute of Endocrinology and Metabolism,Shandong Academy of Clinical Medicine,Jinan 250021,China)

机构地区：[1]山东大学附属省立医院内分泌科,山东省内分泌代谢病临床医学中心,山东省临床医学研究院内分泌代谢研究所,济南250021

出　　处：《国际内分泌代谢杂志》2019年第5期323-326,共4页International Journal of Endocrinology and Metabolism

基　　金：山东省重点研发计划(2017GSF18129).

摘　　要：胰岛细胞增生症是一种罕见的引起成人高胰岛素血症性低血糖的病因,临床特征与胰岛素瘤相似,表现为反复低血糖发作.根据临床表现难以区分胰岛细胞增生症与胰岛素瘤,传统影像学亦不能提高诊断率,最终确诊须依靠病理学.目前胰岛细胞增生症发病机制尚不明确,可能与基因突变、胃旁路手术或多种激素相关.手术切除部分胰腺组织为首选治疗方式,但切除范围尚无统一标准.Nesidioblastosis is a rare cause of persistent hyperinsulinemic hypoglycemia in adults. It is difficult to distinguish between nesidioblastosis and insulinoma based on clinical manifestations, and tradi-tional imageology cannot improve the diagnostic rate. The final diagnosis relies on the histopathologic evalua-tion. The pathogenesis of nesidioblastosis is unknown, it may be related to gene mutation, gastric bypass op-erations or special hormonal situation. The preferred treatment of nesidioblastosis is surgery, but the resec-tion volumes remain undefined.

关 键 词：胰岛细胞增生症 成人 高胰岛素血症性低血糖 胰腺切除术 

分 类 号：R657.5[医药卫生—外科学]