酚妥拉明联合垂体后叶素治疗老年支气管扩张伴大咳血的临床效果  

Clinical effects of phentolamine combined with pituitrin in the treatment of elderly patients with bronchiectasis and massive hemoptysis

作　　者：李菡 周志刚 LI Han;ZHOU Zhi-gang(Shaanxi Triffic Hospital, Xi'an 710068;Ninth Hospital of Xi'an, Xi'an 710054, China)

机构地区：[1]陕西省交通医院,陕西西安710068 [2]西安市第九医院,陕西西安710054

出　　处：《临床医学研究与实践》2019年第29期53-55,共3页Clinical Research and Practice

摘　　要：目的探讨酚妥拉明联合垂体后叶素治疗老年支气管扩张伴大咳血的临床效果。方法选择2016年7月至2018年12月我院收治的80例老年支气管扩张伴大咳血患者为研究对象,根据随机数字表法将其分为对照组和观察组,每组40例。对照组在常规治疗基础上给予垂体后叶素治疗,观察组在常规治疗基础上给予垂体后叶素+酚妥拉明治疗。比较两组临床疗效、症状缓解时间、肺通气功能、血气分析指标、血清炎症因子水平及不良反应发生情况。结果观察组治疗总有效率为95.00%,显著高于对照组的80.00%(P<0.05);观察组的退热、胸痛消失、呛咳消失、咳血消失时间均短于对照组(P<0.05)。治疗后,两组的FEV1、FEV1/FVC均升高,且观察组高于对照组(P<0.05);两组的PaO2均升高,PaCO2均降低,且观察组优于对照组(P<0.05);两组的CRP、IL-6及PCT水平均降低,且观察组低于对照组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论酚妥拉明联合垂体后叶素治疗老年支气管扩张伴大咳血,可有效缓解症状,改善肺通气功能和血气状况,控制炎症反应,具有良好的临床效果,且不良反应少,安全性良好。Objective To study the clinical effects of phentolamine combined with pituitrin in the treatment of elderly patients with bronchiectasis and massive hemoptysis. Methods Eighty elderly patients with bronchiectasis and massive hemoptysis admitted in our hospital from July 2016 to December 2018 were selected as the research objects. The patients were divided into control group and observation group according to random number table method, with 40 cases in each group. The control group was treated with pituitrin on the basis of routine treatment, while the observation group was treated with pituitrin and phentolamine on the basis of routine treatment. The clinical efficacy, symptoms relief time, pulmonary ventilation function, blood gas analysis indexes, serum inflammatory factors level and adverse reactions were compared between the two groups. Results The total effective rate of treatment in the observation group was 95.00%, which was significantly higher than 80.00% of the control group (P<0.05). Antipyretic time, the disappearance time of chest pain, cough and hemoptysis in the observation group were shorter than those in the control group (P<0.05). After treatment, the FEV1 and FEV1/FVC of the two groups were increased, and those in the observation group were higher than the control group (P<0.05);the PaO2 increased and PaCO2 decreased in both groups, and those in the observation group were better than the control group (P<0.05);the levels of CRP, IL-6 and PCT in the two groups were reduced, and those in the observation group were lower than the control group (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion Phentolamine combined with pituitrin in the treatment of elderly patients with bronchiectasis and massive hemoptysis can effectively alleviate symptoms, improve pulmonary ventilation function and blood gas status and control inflammation. It has a good clinical effect, less adverse reactions and good safety.

关 键 词：支气管扩张 咳血 酚妥拉明 垂体后叶素 

分 类 号：R562.22[医药卫生—呼吸系统]