铑催化区域选择性合成2-(2-羟乙基)-4-色满酮  

Rhodium-catalyzed Regioselective Synthesis of 2-(2-Hydroxyethyl)chroman-4-one

作　　者：张世娇[1] 姜志平[1] 高培平[1] 李洪爽 ZHANG Shi-jiao;JIANG Zhi-ping;GAO Pei-ping;LI Hong-shuang(Taian City Central Hospital, Tai'an 271000, China;School of Pharmaceutical Sciences, Shandong First Medical University & Shandong Academy of Medical Scicenes, Tai'an 271016, China)

机构地区：[1]泰安市中心医院,山东泰安271000 [2]山东第一医科大学(山东省医学科学院)药学院,山东泰安271016

出　　处：《精细化工中间体》2019年第4期27-28,58,共3页Fine Chemical Intermediates

基　　金：山东省自然科学基金(ZR2019MB003);山东省重点研发计划(2018GGX109010);泰山医学院高层次课题培育计划(2018GCC16)资助

摘　　要：以水杨醛和3-丁炔-1-醇为起始原料,在[Rh(COD)Cl]2/PPh3/K2CO3催化体系作用下、以KF为添加剂,经区域选择性C-C键及C-O键形成得到2-(2-羟乙基)-4-色满酮。目标化合物的结构经1H NMR和ESI-MS确证。The reaction of salicylaldehyde with 3-butyn-1-ol using [Rh(COD)Cl]2/PPh3/K2CO3 as catalyst and KF as an additive delivered 2-(2-hydroxyethyl) chroman-4-one through C-C bond formation and C-O bond formation in a regioselective manner. The structure of the target compound was determined by 1H NMR and ESI-MS.

关 键 词：铑催化 区域选择性合成 2-(2-羟乙基)-4-色满酮 

分 类 号：O626[理学—有机化学]