颈髓损伤后体位性低血压患者尿中香草扁桃酸变化分析  

Study of urinary vanillylmandelic acid (VMA) level in patients with orthostatic hypotension after cervical spinal cord injury

作　　者：刘传道[1] 吕双喜 昝云强[1] 朱红军[1] 杨卫新[1] Liu Chuan-dao;Lyu Shuang-xi;Zan Yun-qiang;Zhu Hong-jun;Yang Wei-xin(Department of Physical Medicine and Rehabilitation, the First Affiliated Hospital of Soochow University, Suzhou 215006, China)

机构地区：[1]苏州大学附属第一医院康复医学科,江苏苏州215006 [2]克孜勒苏柯尔克孜自治州人民医院康复科,新疆克州845350

出　　处：《中国急救医学》2019年第9期832-834,共3页Chinese Journal of Critical Care Medicine

基　　金：国家自然科学基金(81601966).

摘　　要：目的研究颈髓损伤伴体位性低血压(OH)患者尿中儿茶酚胺代谢产物香草扁桃酸(vanillylmandelic acid, VMA)含量变化,以探讨该类患者自主神经功能变化情况。方法收集颈髓损伤伴OH患者15例,颈髓损伤无OH患者17例,采用色谱法分别测定24 h尿VMA含量,并对测定结果进行统计学分析。结果颈髓损伤伴OH患者24 h尿VMA含量明显低于颈髓损伤无OH组[(12.4±3.27)μmol/24 h vs.(34.5±9.41)μmol/24 h,P<0.05]。结论颈髓损伤伴OH患者24 h尿VMA在评估脊髓损伤后自主神经张力变化有一定的临床意义。Objective To assess autonomic nerve function in patients with orthostatic hypotension ( OH) after cervical spinal cord injury ( SCI ) by evaluating the level of urinary vaniUylmandelic acid ( VMA). Methods The level of 24 hours urinary VMA was determinated in 15 patients with OH after cervical SCI and 17 patients without OH by high - performance liquid chromatography. The results were statistically analyzed according to t - test analysis. Results The urinary VMA concentrations in persons with OH after cervical lesions were markedly reduced compared to patients without OH after cervical SCI [(12.4 ±3. 27)(xmol/24 h vs.(34.5 ±9. 41) pimol/24 h, P < 0. 05 ]. Conclusion The level of 24 h urinary VMA could have the potential to assess the autonomic nerve function in patients post SCI.

关 键 词：颈髓损伤 体位性低血压(OH) 尿香草扁桃酸(VMA) 儿茶酚胺 

分 类 号：R651.2[医药卫生—外科学]