聚ε-己内酯组织工程血管研究进展  

Advances in tissue-engineered vascular graft of poly(ε-caprolactone)

作　　者：徐泽勤 谷涌泉[1] 冯增国[2] 张建[1] XU Zeqin;GU Yongquan;FENG Zengguo;ZHANG Jian(Department of Vascular Surgery, Xuan Wu Hospital and Institute of Vascular Surgery,Capital Medical University, Beijing 100053;School of Materials Science& Engineering, Beijing Institute of Technology, Beijing 100081)

机构地区：[1]首都医科大学宣武医院血管外科,首都医科大学血管外科研究所,北京100053 [2]北京理工大学材料科学与工程学院,北京100081

出　　处：《北京生物医学工程》2019年第5期544-548,共5页Beijing Biomedical Engineering

基　　金：首都卫生发展科研专项(首发2016-1-2012);北京中医药科技发展资金(JJ2015-09)资助

摘　　要：近年来随着心血管疾病患者不断增多,人工血管在临床上的需求不断增长。人工聚合材料聚ε-己内酯[poly(ε-caprolactone),PCL]因具有生物可降解性、良好的力学性能而成为了组织工程血管材料研究的热点。但是单一PCL血管存在疏水性强、细胞黏附亲和力差等缺陷,限制了PCL材料在组织工程领域的应用。为了增强PCL材料的生物相容性,研究者们应用了各种方法对PCL材料进行表面改性或共混成复合物。本文从PCL的表面改性、复合物等方面对其研究现状进行综述。通过表面改性后的PCL及其复合物具有较好的生物相容性,提高了材料的细胞黏附和组织生长性能,这为进一步构建理想小口径人工血管提供了一定的参考。In recent years, there has been a growing demand of tissue engineering vascular grafts for replacement with the increasing number of cardiovascular patients. Poly(ε-caprolactone)(PCL) is a promising biodegradable polymer with good mechanical properties. However, the hydrophobicity, poor cell adhesion and affinity properties of pure PCL material limit its application in the field of tissue engineering. Researchers have applied various methods of surface modification or composite materials to enhance the biocompatibility of PCL scaffold. In this review, recent advances in the surface modification and composite materials of PCL are introduced. The surface modified PCL scaffold and its composite material demonstrate better biocompatibility. Moreover, the cell adhesion and tissue growth of these materials are improved. It provides certain reference for further construction of ideal small-diameter vascular grafts.

关 键 词：组织工程血管 聚Ε-己内酯 表面改性 复合材料 

分 类 号：R318.08[医药卫生—生物医学工程] Q819[医药卫生—基础医学]