保乳手术联合他莫昔芬治疗早期乳腺癌患者的疗效及对hMAM、TGF-β1水平的影响  

Effect of breast conserving surgery combined with tamoxifen on breast cancer and its effect on hMAM and TGF-β1 levels

作　　者：王增辉[1] 李昊楠 李润华[1] 徐甜甜 吴俊兰 WANG Zenghui;LI Haonan;LI Runhua;XU Tiantian;WU Junlan(Department of General Surgery,Tangshan City Union Hospital,Tangshan 063000,Hebei,China;Mammary Department,Lishui Maternal and Child Health Care Hospital,Lishui 323000,Zhejiang,China)

机构地区：[1]唐山市协和医院普外一科,河北唐山063000 [2]丽水市妇幼保健院乳腺科,浙江丽水323000

出　　处：《中国性科学》2019年第9期29-32,共4页Chinese Journal of Human Sexuality

摘　　要：目的分析保乳手术联合他莫昔芬治疗的临床疗效,及对患者hMAM、TGF-β1水平影响。方法选取2016年1月至2017年12月间唐山市协和医院诊治的80例乳腺癌患者作为研究对象。采用随机信封法分为观察组及对照组。对照组采用保乳手术治疗,观察组采用保乳手术联合他莫昔芬治疗;随访3年统计患者1年、2年和3年生存率、复发率及不良反应发生率;检测患者血中TGF-β1水平和hMAM水平。结果观察组患者0年~1年、1年~2年及2年~3年生存率均显著高于对照组,差异具有统计学意义(P<0.05);观察组患0年~1年、1年~2年及2年~3年乳腺癌复发率均显著低于对照组,差异具有统计学意义(P<0.05);治疗后两组患者hMAM、TGF-β1水平均显著低于治疗前,差异具有统计学意义(P<0.05),治疗后观察组患者hMAM、TGF-β1水平均显著低于对照组,差异具有统计学意义(P<0.05);治疗后观察组患者阴道流血不良反应发生率显著低于对照组,差异具有统计学意义(P<0.05)。结论采用保乳手术联合他莫昔芬治疗乳腺癌后可有效提高临床疗效,并降低患者血中hMAM及TGF-β1水平。Objective To analyze the clinical efficacy of breast conserving surgery combined with tamoxifen and its effect on hMAM and TGF-β1 levels.Methods Eighty breast cancer patients diagnosed and treated in Tangshan City Union Hospital were selected as subjects from January 2016 to December 2017. The random envelope method was divided into observation group and control group. The control group was treated with breast-conserving surgery. The observation group was treated with breast-conserving surgery combined with tamoxifen. The 1-, 2-, and 3-year survival rates, recurrence rate, and adverse reaction rate were observed in 3 years. The blood TGF was detected.-β1 level and hMAM level. Results The survival rate of 0~1, 1~2 and 2~3 years in the observation group was significantly higher than that of the control group, and the recurrence rate of breast cancer in 0~1, 1~2 and 2~3 years in the observation group was significantly lower than that of the control group, all with statistically significant differences(all P<0.05). The levels of hMAM and TGF-β1 in the two groups after treatment were significantly lower than those before the treatment, with statistically significant difference(P< 0.05). The level of TGF-β1 was significantly lower than that of the control group(P<0.05). The incidence of adverse reactions of vaginal bleeding after treatment in the observation group was significantly lower than that in the control group, with statistically significant difference(P<0.05). Conclusions Breast conserving surgery combined with tamoxifen in the treatment of breast cancer can effectively improve the clinical efficacy and reduce the levels of hMAM and TGF-β1 in the blood.

关 键 词：保乳手术 他莫昔芬 乳腺癌 疗效 HMAM TGF-Β1 

分 类 号：R711[医药卫生—妇产科学]