长链非编码RNA调控间充质干细胞成软骨分化的研究进展  

Research progress on regulation of long non-coding RNA in differentiation of mesenchymal stem cells into chondrocytes

作　　者：姚楠 李聪聪 宋敏 许学猛[3] 刘文刚[3] 陈国材[2] 陈国茜 叶国柱 YAO Nan;LI Congcong;SONG Min;XU Xuemeng;LIU Wengang;CHEN Guocai;CHEN Guoqian;YE Guozhu(Guangdong Provincial Key Laboratory of Research and Development in Traditional Chinese Medicine,Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine,Guangdong Province,Guangzhou 510095,China;the Fifth Clinical Medical College,Guangzhou University of Chinese Medicine,Guangdong Province,Guangzhou 510095,China;Department of Orthopedics,Guangdong Second Traditional Chinese Medicine Hospital,Guangdong Province,Guangzhou 510095,China)

机构地区：[1]广东省中医药工程技术研究院广东省中医药研究开发重点实验室,广东广州510095 [2]广州中医药大学第五临床医学院,广东广州510095 [3]广东省第二中医院骨科,广东广州510095

出　　处：《中国医药导报》2019年第27期33-36,共4页China Medical Herald

基　　金：广东省自然科学基金项目(2018A030313584);广东省广州市科技计划项目(201804010217);广东省中医药局科研项目(20183001)

摘　　要：修复骨关节炎(OA)引起的关节软骨损伤一直是关节外科的热点与难点。近年来间充质干细胞成为了软骨修复和细胞治疗方面受人关注的细胞。长链非编码RNA(lncRNA)是指一类转录本长度超过200 nt、不编码蛋白质的RNA。最近的研究表明,lncRNA在间充质干细胞成软骨分化过程中呈现出明显的差异表达,并且在间充质干细胞成软骨分化过程中发挥着重要的调控作用。本文综述了lncRNA DANCR、lncRNA HOTAIRM1-1、lncRNA ROCR、lncRNA ZBED3-AS1和lncRNA HIT调控间充质干细胞成软骨分化的研究,并探讨了当前研究存在的问题,以期将来为OA的细胞治疗提供参考。Repair of articular cartilage injury caused by osteoarthritis (OA) has always been a hotspot and difficult point in joint surgery. Mesenchymal stem cells have become the focus of cartilage repair and cell therapy in recent years. Long non-coding RNA (lncRNA) refers to a class of RNA whose transcript length exceeds 200 nt and does not code for proteins. Recent studies have shown that lncRNA is significantly differentially expressed during the differentiation of mesenchymal stem cells into chondrocytes and plays an important role in the process of the differentiation of mesenchymal stem cells into chondrocytes. This paper reviews the research on regulation of lncRNA DANCR, lncRNA HOTAIRM1-1, lncRNA ROCR, lncRNA ZBED3-AS1 and lncRNA HIT in differentiation of mesenchymal stem cells into chondrocytes, and discusses the existing problems in current studies, in order to provide references for the future cell therapy of OA.

关 键 词：长链非编码RNA 间充质干细胞 分化 软骨细胞 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]