基于关联规则与实体语法系统探究中药化妆品配方设计  

Exploring the formula design of traditional Chinese medicine cosmetics based on association rules and entity grammar system

作　　者：贾聪敏 过红玲[1] 曹婷婷 雷巧灵 张宪宝[1] 王耘[1] JIA Congmin;GUO Hongling;CAO Tingting;LEI Qiaoling;ZHANG Xianbao;WANG Yun(Research Center of Traditional Chinese Medicine Information Engineering,Beijing University of Chinese Medicine,Beijing 100102,China)

机构地区：[1]北京中医药大学中药信息工程研究中心

出　　处：《中国医药导报》2019年第27期126-129,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81673697、81373985)

摘　　要：目的基于关联规则与实体语法系统设计安全、合理、有效的含有中草药化学成分的中药化妆品配方。方法收集2014~2015年国内外所有含中草药化学成分的化妆品配方数据,利用关联规则发现各类化妆品产品的配方规律,基于所发现的规律和化妆品固有的配方结构,结合实体语法系统建立新的化妆品配方设计模型。结果根据模型设计出符合祛痘加美白化妆水配方结构和功效的新配方。将新配方进行筛选、定量、打样以及功效验证,面部痤疮者使用后均达到了良好的效果。结论利用关联规则与实体语法系统进行祛痘加美白类化妆品的配方设计方法具有一定的可行性,为其他类中药化妆品的配方设计提供了一定的参考,利于扩大中药在美容护肤方面的应用。Objective To design a safe, reasonable and effective Chinese medicine cosmetics formula containing chinese herbal medicine chemical composition based on association rules and entity grammar system. Methods Data of cosmetic formulations containing Chinese herbal medicine chemical composition from 2014 to 2015 were collected, while association rules were used to discover the formulation rules of various cosmetic products. Based on the discovered rules and the inherent formula structure of cosmetics, a new formula design model of cosmetics was established by combining entity grammar system. Results According to the model, a new formula which accords with the structure and efficacy of acne-removing and whitening lotion formula was designed. The new formula had been screened, quantified, proofed and validated, while good results had been achieved in acne patients after use. Conclusion It is feasible to use association rules and entity grammar system to design formula of acne-eliminating and whitening cosmetics, which provides a reference for the formulation design of other traditional Chinese medicine cosmetics and helps to expand the application of traditional Chinese medicine in cosmetology and skin care.

关 键 词：中药化学成分 化妆品配方设计 关联规则 实体语法系统 

分 类 号：R284[医药卫生—中药学]