原发性中枢神经系统DLBCL的临床病理特点与生存预后研究  

Study on Clinicopathological Features and Survival Prognosis of DLBCL

作　　者：林玲[1] 陈为民[1] 陈碧云[1] 林芸[1] 廖丽昇[1] LIN Ling;CHEN Weimin;CHEN Biyun;LIN Yun;LIAO Lisheng(Department of Hematology,Fujian Provincial Hospital,Fuzhou Fujian 350001,China)

机构地区：[1]福建省立医院血液科

出　　处：《中国卫生标准管理》2019年第18期48-51,共4页China Health Standard Management

摘　　要：目的研究原发性中枢神经系统弥漫性大B细胞淋巴瘤(DiffuseLarge B-cell Lymphomas,DLBCL)的临床病理特点及其与生存预后的关系。方法收集我院2010年10月—2015年10月收治的原发性中枢神经系统DLBCL患者37例,运用免疫组化技术标记所选病例,同时对患者的生存预后情况进行评估。结果37例患者经治疗后,生存期>3年24例,占比64.86%;生存期1~2年13例,占比35.14%;其中,患者的年龄、体力活动状态(performance status,PS)、国际预后指数(International Prognostic Index,IPI)、免疫学分型与患者预后密切相关(P<0.05)。结论患者年龄、免疫学分型、PS和IPI评分极易影响到DLBCL患者的预后,而甲氨蝶呤为基础的化疗联合或不联合WBRT可作为临床治疗DLBCL的主要手段,但在具体治疗过程中,还应结合患者实际病情,以确保治疗疗效、最大限度改善预后。Objective To study the clinicopathological characteristics and its relationship with survival and prognosis of diffuse large b-cell lymphomas(DLBCL).Methods A total of 37 patients with primary central nervous system DLBCL admitted to our hospital from October 2010 to October 2015 were collected.Results After treatment,24 patients(64.86%)survived>for 3 years.The survival period was 1~2 years in 13 cases,accounting for 35.14%.Among them,patients'age,physical activity status(PS),international prognostic index(IPI)and immune credit type are closely related to patients'prognosis(P<0.05).Conclusion Patients'age,immunological credit type,PS and IPI score are extremely likely to affect the prognosis of DLBCL patients.Surgical resection and methotrexate chemotherapy can be used as the main clinical treatment for DLBCL.

关 键 词：原发性中枢神经系统弥漫性大B细胞淋巴瘤 临床病理特点 免疫组化技术 治疗 单因素分析 生存预后 

分 类 号：R651[医药卫生—外科学]