孕期乙型肝炎活动患者抗病毒治疗效果  

Effect of Antiviral Therapy on Patients With Active Hepatitis B During Pregnancy

作　　者：王加[1] 芦雅苹[1] 陆琳琳[1] WANG Jia;LU Yaping;LU Linlin(Obstetrics Department,JiangmenCentral Hospital,Jiangmen Guangdong 529030,China)

机构地区：[1]江门市中心医院产科

出　　处：《中国卫生标准管理》2019年第18期103-105,共3页China Health Standard Management

摘　　要：目的研究孕期乙型肝炎活动患者抗病毒治疗临床结局。方法选择2017年2月—2019年1月医院收治的孕期乙型肝炎活动患者83例,分为对照组40例和观察组43例。对照组采取传统保肝治疗,观察组采取抗病毒治疗。比较两组的妊娠期肝病结局、严重不良事件、新生儿结局。结果观察组产前谷丙转氨酶(ALT)复常率90.70%、乙肝病毒的脱氧核糖核酸(HBVDNA)转阴率60.47%,分别高于对照组的17.50%和7.50%,差异具有统计学意义(P<0.05)。观察组终止妊娠率2.33%、非生育住院率6.98%,分别低于对照组的20.00%和27.50%,差异具有统计学意义(P<0.05);观察组新生儿乙肝表面抗原(HBsAg)阳性率0.00%,低于对照组的15.00%,差异具有统计学意义(P<0.05)。结论对孕期隐性肝炎活动患者,采取积极的抗病毒治疗,能够有效改善妊娠期肝病结局,减少严重不良事件的发生,同时改善新生儿结局,降低了HBV的母婴传播,具有重要的临床价值。Objective To study the clinical outcome of antiviral therapy in patients with active hepatitis B during pregnancy.Methods From February 2017 to January 2019,83 patients with hepatitis B activity during pregnancy were divided into control group(n=40)and observation group(n=43).The control group was treated with traditional liver protection treatment,and the observation group was treated with antiviral therapy.The outcome of liver disease during pregnancy,serious adverse events and neonatal outcome were compared between the two groups.Results The recovery rate of ALT(glutamic pyruvic transaminase)and the negative conversion rate of DNA(deoxyribonucleic acid of hepatitis B virus)in the observation group were 90.70%and 60.47%,respectively,which were higher than those in the control group.There was significant difference between 17.50%and 7.50%(P<0.05).The termination rate of pregnancy and the hospitalization rate of non-fertility in the observation group were 2.33%and 6.98%,respectively,which were significantly lower than those in the control group 20.00%and 27.50%,P<0.05,and the positive rate of HBsAg(hepatitis B surface antigen)in the observation group was 0.00%,which was significantly lower than that in the control group 15.00%,P<0.05.Conclusion Active antiviral therapy can effectively improve the outcome of liver disease during pregnancy,reduce the occurrence of serious adverse events and improve the occurrence of severe adverse events.Neonatal outcome reduces the motherto-child transmission of HBV and has important clinical value.

关 键 词：孕期 乙型肝炎 活动 抗病毒治疗 妊娠结局 治疗效果 

分 类 号：R973[医药卫生—药品]