血清CG、CRP水平与慢性阻塞性肺疾病患者肝肺功能的关系  

The relationship between serum CG and CRP levels and liver and lung function in patients with chronic obstructive pulmonary disease

作　　者：杨俊[1] 杜苏丰 和东升 Yang Jun;Du Su-feng;He Dong-sheng(Department of Respiratory Medicine,Ankang Central Hospital,Ankang 725000,China;Department of Respiratory Medicine,Xi'an ChestHospital,Xi' an 710100,China)

机构地区：[1]陕西省安康市中心医院呼吸内科,安康725000 [2]西安市胸科医院呼吸内科,西安710100

出　　处：《湖南师范大学学报（医学版）》2019年第5期100-102,共3页Journal of Hunan Normal University(Medical Sciences)

摘　　要：目的:探讨血清甘胆酸(CG)、C反应蛋白(CRP)水平与慢性阻塞性肺疾病(COPD)患者肝、肺功能的关系.方法:选择2016年1月~2018年7月我院收治的COPD患者103例,根据病情不同分为急性加重期组63例,稳定期组40例,另取同期健康体检者30例作为健康对照组.分别检测各组血清CG、CRP水平,肝功能指标及肺功能指标水平,并分析其相关性.结果:急性加重期组患者血清CG、CRP水平,均明显高于稳定期组与健康对照组,而稳定期组血清CG、CRP明显高于健康对照组.急性加重期组患者ALT、AST、Alb、Tbil水平均明显高于稳定期组与健康对照组,而稳定期组ALT、AST、Tbil又明显高于健康对照组.急性加重期组患者FEV1、FEV1/FVC水平明显低于稳定期组与健康对照组,而稳定期组FEV1、FEV1/FVC明显低于健康对照组.经Pearson相关性分析可得:COPD患者血清CG、CRP水平与ALT、AST、Tbil呈正相关关系,与FEV1、FEV1/FVC呈负相关关系,与Alb无相关性.结论:血清CG以及CRP水平在COPD的发生、发展过程中可能发挥着至关重要的作用,同时可作为反映患者肝、肺功能的敏感指标,值得临床重点关注.Objective To study the relationship between serum cholic acid (CG) and C reactive protein (CRP) levels in patients with chronic obstructive pulmonary disease and their pulmonary and pulmonary functions. Methods Selected 103 patients with COPD from January 2016 to July 2018 in our hospital, which were divided into acute exacerbation group (63 cases) and stable group (40 cases) according to different conditions. Another 30 healthy people were selected as healthy control group at the same period. The levels of serum CG, CRP, liver function indexes and pulmonary function indexes in each group were analyzed respectively. Results The serum levels of CG and CRP in the acute exacerbation group were significantly higher than those in the stable group and the healthy control group, while the serum CG and CRP in the stable group were significantly higher than those in the healthy control group. The levels of ALT, AST, Alb and Tbil in the acute exacerbation group were significantly higher than those in the stable group and the healthy control group, while the ALT, AST and Tbil in the stable group were significantly higher than those in the healthy control group. The levels of FEV1 and FEV1/FVC in the acute exacerbation group were significantly lower than those in the stable group and the healthy control group, while the FEV1 and FEV 1/FVC in the stable group were significantly lower than those in the healthy control group. Pearson correlation analysis showed that the serum levels of CG and CRP were positively correlated with ALT, AST and Tbil, and negatively correlated with FEV1 and FEV 1/FVC, and there was no correlation with Alb n COPD patients. Conclusion The serum CG and CRP levels in patients with chronic obstructive pulmonary disease, may play a crucial role in the development process, and can be used as a sensitive index to reflect the liver, lung function, and is worthy of clinical attention.

关 键 词：慢性阻塞性肺疾病 肝胆酸 C反应蛋白 肝功能 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统] R544.1[医药卫生—内科学]