Altered chromatin recruitment by FOXA1 mutations promotes androgen independence and prostate cancer progression  

作　　者：Bohan Xu Bing Song Xiaodong Lu Jung Kim Ming Hu Jonathan C.Zhao Jindan Yu 

机构地区：[1]Department of Medicine,Division of Hematology/Oncology,Northwestern University Feinberg School of Medicine,Chicago,IL 60611,USA [2]Department of Quantitative Health Sciences,Lerner Research Institute,Cleveland Clinic,Cleveland,OH 44195,USA [3]Robert H. Lurie Comprehensive Cancer Center,Northwestern University Feinberg School of Medicine,Chicago,IL 60611,USA [4]Department of Biochemistry and Molecular Genetics,Northwestern University Feinberg School of Medicine,Chicago,IL 60611,USA

出　　处：《Cell Research》2019年第9期773-775,共3页细胞研究（英文版）

摘　　要：Dear Editor,F0XA1,a forkhead(FKHD)family transcription factor,is highly expressed in the epithelium of endoderm-derived organs, including the prostate gland.1 Transgenic mouse studies have shown that F0XA1 expression is required for prostate epithelial cell differentiation and ductal morphogenesis during development and for the maintenance of this differentiated epithelial phenotype in the adult. Mechanistically, F0XA1 binds FKHD motifs in the DNA to open chromatin and in crease local accessibility.

关 键 词：FOXA1 FKHD DNA 

分 类 号：Q[生物学]