中国中医科学院著名老中医治疗冠心病用药规律分析  

Analysis on the Regularity of Prescription and Medicine in Treating Coronary Heart Disease by Distinguished Veteran TCM Doctors in China Academy of Chinese Medical Sciences

作　　者：董蓉蓉 何庆勇[2] 李敏 荆鲁[1] 张松青[3] DONG Rongrong;HE Qingyong;LI Min;JING Lu;ZHANG Songqing(Eye Hospital of China Academy of Chinese Medical Sciences,Beijing 100040,China)

机构地区：[1]中国中医科学院眼科医院,北京100040 [2]中国中医科学院广安门医院 [3]北京市海淀区中医医院

出　　处：《中西医结合心脑血管病杂志》2019年第18期2732-2736,共5页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的利用数据挖掘技术对中国中医科学院著名老中医治疗冠心病的用药规律进行总结。方法收集1956年—2017年中国中医科学院著名老中医著作,运用中医传承辅助平台(TCMISS)V2.5,利用关联规则、改进互信息法、复杂系统熵聚类、无监督的熵层次分析等数据挖掘技术对证候要素、常用单药、对药、角药、药物关联规则、核心药物组合及新方发现进行分析。结果共纳入医案102则,药物共178味。证候要素排在前3位的分别是血瘀(64次,占62.3%)、气虚(44次,占43.1%)、痰浊(41次,占40.2%)。最常用的单药为丹参(64次,占62.7%)、川芎(50次,占49.0%)、赤芍(43次,占42.2%)。最常用的对药为川芎-丹参(36次,占35.1%),最常用的角药为红花-赤芍-川芎(25次,占24.5%)。关联度高的中药组合为红花+赤芍→川芎(置信度为0.9615)。通过熵方法得出22组用于新方聚类的核心组合为薤白-半夏-瓜蒌和黄芪-甘草-丹参等;得出11组治疗冠心病的新处方。结论临床治疗冠心病及开发治疗冠心病新药优先考虑以血瘀、气虚、痰浊等为主要适应证,单药、对药、角药优先考虑丹参、川芎、赤芍等;配伍规律优先考虑红花、赤芍配伍川芎等;核心药物组合多为瓜蒌薤白半夏汤、生脉饮等临床常用治疗冠心病方剂的药物组成,候选新处方治法除强调活血、益气、祛痰外,还兼顾安神、行气、健脾、疏肝等。Objective Based on data mining technology,the regularity of prescription and medicine in treating coronary heart disease by distinguished veteran traditional Chinese medicine (TCM) doctors in China Academy of Chinese Medical Sciences was analyzed. Methods The works of distinguished veteran TCM doctors in China Academy of Chinese Medical Sciences were collected from 1956 to 2017.TCM inheritance support system(V2.5) was used to analysis the syndrome elements,common single drugs,pairs of drugs,triangle drugs,association rules of drugs,combination of the core drugs and prescriptions newfound by the methods of association rules,improved mutual information entropy clustering,complex systems entropy clustering,and unsupervised entropy hierarchical clustering. Results A total of 102 cases were included,containing 178 flavor drugs.The top three syndrome elements were blood stasis (64 times,62.3%),qi deficiency (44 times,43.1%),and phlegm-turbid (41 times,40.2%).The most commonly used herbal medicine were Danshen (64 times,62.7%),Chuanxiong(50 times,49.0%),Chishao(43 times,42.2%).The most commonly used pairs of drugs was Chuanxiong-Danshen(36 times,35.1%).The most commonly used triangle drugs was Honghua-Chishao-Chuanxiong(25 times,24.5%).The drug combinations in high association was Honghua+Chishao→Chuanxiong (confidence 0.961 5).There were 22 core combinations for the clustering of new prescriptions and 11 groups of new prescriptions for coronary heart disease. Conclusion For clinical treatment and development of new drugs for coronary heart disease,the priority choice of syndrome elements were blood stasis,qi deficiency,and phlegm-turbid;The priority choice of single drugs,pair of drugs,and triangle drugs were Danshen,Chuanxiong,and Chishao;the priority choice of compatibility rule was Honghua,Chishao with Chuanxiong;the core drug combinations were Gualou Xiebai Banxia decoction and Shengmai drink and so on. In addition to the emphasis on activating blood,replenishing Qi,and eliminating phlegm,consideration should be

关 键 词：冠心病 用药规律 著名老中医 中医传承辅助平台 

分 类 号：R541.4[医药卫生—心血管疾病] R289.5[医药卫生—内科学]